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10.1007/s40520-021-01894-z http://scihub22266oqcxt.onion/10.1007/s40520-021-01894-z 34118024!8195723!34118024     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+Clin+Exp+Res 2021 ; 33 (7): 2031-2041 Nephropedia Template TP {{tp|p=34118024|t=2021. Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review |pdf=|usr=}}{{34118024}} gab.com Text Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review JO: Aging Clin Exp Res http://www.kidney.de/pget.php?&tw=1&pmid=34118024 #FOAvip BACKGROUND: The rapid global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has re-ignited interest in the possible role of vitamin D in modulation of host responses to respiratory pathogens. Indeed, vitamin D supplementation has been proposed as a potential preventative or therapeutic strategy. Recommendations for any intervention, particularly in the context of a potentially fatal pandemic infection, should be strictly based on clinically informed appraisal of the evidence base. In this narrative review, we examine current evidence relating to vitamin D and COVID-19 and consider the most appropriate practical recommendations. OBSERVATIONS: Although there are a growing number of studies investigating the links between vitamin D and COVID-19, they are mostly small and observational with high risk of bias, residual confounding, and reverse causality. Extrapolation of molecular actions of 1,25(OH)(2)-vitamin D to an effect of increased 25(OH)-vitamin D as a result of vitamin D supplementation is generally unfounded, as is the automatic conclusion of causal mechanisms from observational studies linking low 25(OH)-vitamin D to incident disease. Efficacy is ideally demonstrated in the context of adequately powered randomised intervention studies, although such approaches may not always be feasible. CONCLUSIONS: At present, evidence to support vitamin D supplementation for the prevention or treatment of COVID-19 is inconclusive. In the absence of any further compelling data, adherence to existing national guidance on vitamin D supplementation to prevent vitamin D deficiency, predicated principally on maintaining musculoskeletal health, appears appropriate. Twit Text FOAVip Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review ????Aging Clin Exp Res http://www.kidney.de/pget.php?&tw=1&pmid=34118024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34118024 #FOAvip English Wikipedia <ref>{{Cite pmid|34118024}}</ref> Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review #MMPMID34118024 Raisi-Estabragh Z; Martineau AR; Curtis EM; Moon RJ; Darling A; Lanham-New S; Ward KA; Cooper C; Munroe PB; Petersen SE; Harvey NC Aging Clin Exp Res 2021[Jul]; 33 (7): 2031-2041 PMID34118024show ga BACKGROUND: The rapid global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has re-ignited interest in the possible role of vitamin D in modulation of host responses to respiratory pathogens. Indeed, vitamin D supplementation has been proposed as a potential preventative or therapeutic strategy. Recommendations for any intervention, particularly in the context of a potentially fatal pandemic infection, should be strictly based on clinically informed appraisal of the evidence base. In this narrative review, we examine current evidence relating to vitamin D and COVID-19 and consider the most appropriate practical recommendations. OBSERVATIONS: Although there are a growing number of studies investigating the links between vitamin D and COVID-19, they are mostly small and observational with high risk of bias, residual confounding, and reverse causality. Extrapolation of molecular actions of 1,25(OH)(2)-vitamin D to an effect of increased 25(OH)-vitamin D as a result of vitamin D supplementation is generally unfounded, as is the automatic conclusion of causal mechanisms from observational studies linking low 25(OH)-vitamin D to incident disease. Efficacy is ideally demonstrated in the context of adequately powered randomised intervention studies, although such approaches may not always be feasible. CONCLUSIONS: At present, evidence to support vitamin D supplementation for the prevention or treatment of COVID-19 is inconclusive. In the absence of any further compelling data, adherence to existing national guidance on vitamin D supplementation to prevent vitamin D deficiency, predicated principally on maintaining musculoskeletal health, appears appropriate. |*COVID-19[MESH] |*Vitamin D Deficiency[MESH] |Humans[MESH] |SARS-CoV-2[MESH] |Vitamin D[MESH]Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence revi(epmc).pdf DeepDyve Pubget Overpricing