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10.1016/j.humimm.2021.05.003 http://scihub22266oqcxt.onion/10.1016/j.humimm.2021.05.003 34116863!8108382!34116863     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34116863&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Immunol 2021 ; 82 (8): 551-560 Nephropedia Template TP {{tp|p=34116863|t=2021. Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms |pdf=|usr=}}{{34116863}} gab.com Text Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms JO: Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34116863 #FOAvip Given the highly polymorphic nature of Human Leukocyte Antigen (HLA) molecules, it is not surprising that they function as key regulators of the host immune response to almost all invading pathogens, including SARS-CoV-2, the etiological agent responsible for the recent COVID-19 pandemic. Several correlations have already been established between the expression of a specific HLA allele/haplotype and susceptibility/progression of SARS-CoV-2 infection and new ones are continuously emerging. Protective and harmful HLA variants have been described in both mild and severe forms of the disease, but considering the huge amount of existing variants, the data gathered in such a brief span of time are to some extent confusing and contradictory. The aim of this mini-review is to provide a snap-shot of the main findings so far collected on the HLA-SARS-CoV-2 interaction, so as to partially untangle this intricate yarn. As key factors in the generation of antigenic peptides to be presented by HLA molecules, ERAP1 and ERAP2 role in SARS-CoV-2 infection will be revised as well. Twit Text FOAVip Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms ????Hum Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34116863 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34116863 #FOAvip English Wikipedia <ref>{{Cite pmid|34116863}}</ref> Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms #MMPMID34116863 Saulle I; Vicentini C; Clerici M; Biasin M Hum Immunol 2021[Aug]; 82 (8): 551-560 PMID34116863show ga Given the highly polymorphic nature of Human Leukocyte Antigen (HLA) molecules, it is not surprising that they function as key regulators of the host immune response to almost all invading pathogens, including SARS-CoV-2, the etiological agent responsible for the recent COVID-19 pandemic. Several correlations have already been established between the expression of a specific HLA allele/haplotype and susceptibility/progression of SARS-CoV-2 infection and new ones are continuously emerging. Protective and harmful HLA variants have been described in both mild and severe forms of the disease, but considering the huge amount of existing variants, the data gathered in such a brief span of time are to some extent confusing and contradictory. The aim of this mini-review is to provide a snap-shot of the main findings so far collected on the HLA-SARS-CoV-2 interaction, so as to partially untangle this intricate yarn. As key factors in the generation of antigenic peptides to be presented by HLA molecules, ERAP1 and ERAP2 role in SARS-CoV-2 infection will be revised as well. |*Antigen Presentation[MESH] |*Polymorphism, Genetic[MESH] |Aminopeptidases/*genetics/immunology[MESH] |Animals[MESH] |Antigens, Viral/*immunology[MESH] |COVID-19/diagnosis/*genetics/immunology/virology[MESH] |Epitopes[MESH] |HLA Antigens/*genetics/immunology[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Minor Histocompatibility Antigens/*genetics/immunology[MESH]Antigen presentation in SARS-CoV-2 infection: the role of class I HLA (epmc).pdf DeepDyve Pubget Overpricing