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10.1016/j.nut.2021.111340 http://scihub22266oqcxt.onion/10.1016/j.nut.2021.111340 34116393!8102075!34116393     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nutrition 2021 ; 89 (ä): 111340 Nephropedia Template TP {{tp|p=34116393|t=2021. Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2) |pdf=|usr=}}{{34116393}} gab.com Text Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2) JO: Nutrition http://www.kidney.de/pget.php?&tw=1&pmid=34116393 #FOAvip OBJECTIVES: The viral entry of SARS-CoV-2 requires host-expressed TMPRSS2 to facilitate the viral spike protein priming. This study aims to test the hypothesis that magnesium (Mg) treatment leads to DNA methylation changes in TMPRSS2. METHODS: This study is nested within the Personalized Prevention of Colorectal Cancer Trial, a double-blind 2 x 2 factorial randomized controlled trial, which enrolled 250 participants from Vanderbilt University Medical Center. RESULTS: We found that 12 wk of personalized Mg treatment significantly increased 5-methylcytosine methylation at cg16371860 (TSS1500, promoter) by 7.2% compared to the placebo arm (decreased by 0.1%) in those ages < 65 y. The difference remained statistically significant after adjusting for age, sex, and baseline methylation as well as correction for false discovery rate (adjusted P = 0.014). Additionally, Mg treatment significantly reduced 5-hydroxymethylcytosine levels at cg26337277 (close proximity to TSS200 and the 5' untranslated region, promoter) by 2.3% compared to an increase of 7.1% in the placebo arm after adjusting for covariates in those ages < 65 y (P = 0.003). The effect remained significant at a false discovery rate of 0.10 (adjusted P = 0.088). CONCLUSIONS: Among individuals ages < 65 y with calcium-to-magnesium intake ratios equal to or over 2.6, reducing the ratio to around 2.3 increased 5-methylcytosine modifications (i.e., cg16371860) and reduced 5-hydroxymethylcytosine modifications (i.e., cg26337277) in the TMPRSS2 gene. These findings, if confirmed, provide another mechanism for the role of Mg intervention in the prevention of COVID-19 and treatment of early and mild disease by modifying the phenotype of the TMPRSS2 genotype. Twit Text FOAVip Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2) ????Nutrition http://www.kidney.de/pget.php?&tw=1&pmid=34116393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34116393 #FOAvip English Wikipedia <ref>{{Cite pmid|34116393}}</ref> Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2) #MMPMID34116393 Fan L; Zhu X; Zheng Y; Zhang W; Seidner DL; Ness R; Murff HJ; Yu C; Huang X; Shrubsole MJ; Hou L; Dai Q Nutrition 2021[Sep]; 89 (ä): 111340 PMID34116393show ga OBJECTIVES: The viral entry of SARS-CoV-2 requires host-expressed TMPRSS2 to facilitate the viral spike protein priming. This study aims to test the hypothesis that magnesium (Mg) treatment leads to DNA methylation changes in TMPRSS2. METHODS: This study is nested within the Personalized Prevention of Colorectal Cancer Trial, a double-blind 2 x 2 factorial randomized controlled trial, which enrolled 250 participants from Vanderbilt University Medical Center. RESULTS: We found that 12 wk of personalized Mg treatment significantly increased 5-methylcytosine methylation at cg16371860 (TSS1500, promoter) by 7.2% compared to the placebo arm (decreased by 0.1%) in those ages < 65 y. The difference remained statistically significant after adjusting for age, sex, and baseline methylation as well as correction for false discovery rate (adjusted P = 0.014). Additionally, Mg treatment significantly reduced 5-hydroxymethylcytosine levels at cg26337277 (close proximity to TSS200 and the 5' untranslated region, promoter) by 2.3% compared to an increase of 7.1% in the placebo arm after adjusting for covariates in those ages < 65 y (P = 0.003). The effect remained significant at a false discovery rate of 0.10 (adjusted P = 0.088). CONCLUSIONS: Among individuals ages < 65 y with calcium-to-magnesium intake ratios equal to or over 2.6, reducing the ratio to around 2.3 increased 5-methylcytosine modifications (i.e., cg16371860) and reduced 5-hydroxymethylcytosine modifications (i.e., cg26337277) in the TMPRSS2 gene. These findings, if confirmed, provide another mechanism for the role of Mg intervention in the prevention of COVID-19 and treatment of early and mild disease by modifying the phenotype of the TMPRSS2 genotype. |*COVID-19[MESH] |*Magnesium[MESH] |DNA Methylation[MESH] |Humans[MESH] |Promoter Regions, Genetic[MESH] |SARS-CoV-2[MESH]Magnesium treatment on methylation changes of transmembrane serine pro(epmc).pdf DeepDyve Pubget Overpricing