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10.1016/j.intimp.2021.107825 http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107825 34116286!8169316!34116286     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2021 ; 98 (ä): 107825 Nephropedia Template TP {{tp|p=34116286|t=2021. Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity |pdf=|usr=}}{{34116286}} gab.com Text Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34116286 #FOAvip The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Delta32 variant (rs333) in COVID-19. The CCR5-Delta32 was genotyped in 801 patients (353 in the intensive care unit, ICU) and 660 healthy controls, and the deletion was significantly less frequent in hospitalysed COVID-19 than in healthy controls (p = 0.01, OR = 0.66, 95%CI = 0.49-0.88). Of note, we did not find homozygotes among the patients, compared to 1% of the controls. The CCR5 transcript was measured in leukocytes from 85 patients and 40 controls. We found a significantly higher expression of the CCR5 transcript among the patients, with significant difference when comparing the non-deletion carriers (controls = 35; patients = 81; p = 0.01). ICU-patients showed non-significantly higher expression than no-ICU cases. Our study points to CCR5 as a genetic marker for COVID-19. The pharmacological targeting of CCR5 should be a promising treatment for COVID-19. Twit Text FOAVip Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34116286 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34116286 #FOAvip English Wikipedia <ref>{{Cite pmid|34116286}}</ref> Variant-genetic and transcript-expression analysis showed a role for the chemokine-receptor CCR5 in COVID-19 severity #MMPMID34116286 Cuesta-Llavona E; Gomez J; Albaiceta GM; Amado-Rodriguez L; Garcia-Clemente M; Gutierrez-Rodriguez J; Lopez-Alonso I; Hermida T; Enriquez AI; Hernandez-Gonzalez C; Gil-Pena H; Dominguez-Garrido E; Perez-Oliveira S; Alvarez V; Lopez-Larrea C; Suarez-Alvarez B; Tranche S; Jimeno-Demuth FJ; Coto E Int Immunopharmacol 2021[Sep]; 98 (ä): 107825 PMID34116286show ga The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Delta32 variant (rs333) in COVID-19. The CCR5-Delta32 was genotyped in 801 patients (353 in the intensive care unit, ICU) and 660 healthy controls, and the deletion was significantly less frequent in hospitalysed COVID-19 than in healthy controls (p = 0.01, OR = 0.66, 95%CI = 0.49-0.88). Of note, we did not find homozygotes among the patients, compared to 1% of the controls. The CCR5 transcript was measured in leukocytes from 85 patients and 40 controls. We found a significantly higher expression of the CCR5 transcript among the patients, with significant difference when comparing the non-deletion carriers (controls = 35; patients = 81; p = 0.01). ICU-patients showed non-significantly higher expression than no-ICU cases. Our study points to CCR5 as a genetic marker for COVID-19. The pharmacological targeting of CCR5 should be a promising treatment for COVID-19. |*Genetic Variation[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |COVID-19/diagnosis/*genetics/virology[MESH] |Case-Control Studies[MESH] |Female[MESH] |Genetic Predisposition to Disease[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Male[MESH] |Middle Aged[MESH] |Patient Admission[MESH] |Phenotype[MESH] |Receptors, CCR5/*genetics[MESH] |Risk Assessment[MESH] |Risk Factors[MESH] |SARS-CoV-2/*pathogenicity[MESH]Variant-genetic and transcript-expression analysis showed a role for t(epmc).pdf DeepDyve Pubget Overpricing