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10.1016/j.cmi.2021.05.036

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suck abstract from ncbi


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pmid34116205      Clin+Microbiol+Infect 2021 ; 27 (9): 1242-1249
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  • The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis #MMPMID34116205
  • Kayi I; Madran B; Keske S; Karanfil O; Arribas JR; Pshenismall es, Cyrillichnaya N; Petrosillo N; Gonen M; Ergonul O
  • Clin Microbiol Infect 2021[Sep]; 27 (9): 1242-1249 PMID34116205show ga
  • BACKGROUND: The prevalence of SARS-CoV-2 infection among health care workers (HCWs) provides information about the spread of COVID-19 within health care facilities, and the risk groups. OBJECTIVES: We aimed to describe the rate of SARS-CoV-2 seroprevalence and its determinants among HCWs. DATA SOURCES: We used Web of Science, PubMed, Scopus, MEDLINE, EBSCOhost and Cochrane Library. STUDY ELIGIBILITY CRITERIA: We included the reports of SARS-CoV-2 seroprevalence with a sample size of minimum 1000 HCWs. METHODS: The study was registered at the International Prospective Register of Systematic Reviews (PROSPERO, no. CRD42021230456). We used PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. The keywords were "COVID-19", "SARS-CoV-2", "Coronavirus", "seroprevalence", "health care workers" and "risk factors". RESULTS: In total 4329 reports were retrieved, duplications were removed; after filtering according to the title and abstract, 25 studies were selected. Risk of bias was assessed in 25 studies; it was low in 13 studies, medium in four studies, and high in eight studies. In meta-analysis using the random effect model, the weighted average of seroprevalence was calculated as 8% (95% CI 6-10%). The pooled seroprevalence rates of the selected variables that have a rate above the average were male HCWs with 9% (95% CI 7-11%); HCWs from ethnic minorities with 13% (95% CI 9-17%); high exposure 9% (95% CI 6-13%); exposure to the virus outside the health care setting 22% (95% CI 14-32%). CONCLUSIONS: Our analysis indicates a SARS-CoV-2 seroprevalence rate of 8% among studies that included >1000 HCWs for the year 2020, before vaccinations started. The most common risk factors associated with higher seroprevalence rate were ethnicity, male gender and having a higher number of household contacts. Working as a frontline HCW was inconsistent in its association with higher seroprevalence.
  • |COVID-19/*epidemiology/ethnology/virology[MESH]
  • |Female[MESH]
  • |Health Personnel/*statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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