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10.1016/j.ijbiomac.2021.06.035

http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.06.035
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34116092!ä!34116092

suck abstract from ncbi


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pmid34116092      Int+J+Biol+Macromol 2021 ; 185 (ä): 20-30
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  • Role of chitosan based nanomedicines in the treatment of chronic respiratory diseases #MMPMID34116092
  • Gulati N; Dua K; Dureja H
  • Int J Biol Macromol 2021[Aug]; 185 (ä): 20-30 PMID34116092show ga
  • Chitosan-loaded nanomedicines provide a greater opportunity for the treatment of respiratory diseases. Natural biopolymer chitosan and its derivatives have a large number of proven pharmacological actions like antioxidant, wound healing, immuno-stimulant, hypocholesterolemic, antimicrobial, obesity treatment, anti-inflammatory, anticancer, bone tissue engineering, antifungal, regenerative medicine, anti-diabetic and mucosal adjuvant, etc. which attracted its use in the pharmaceutical industry. As compared to other polysaccharides, chitosan has excellent mucoadhesive characteristics, less viscous, easily modified into the chemical and biological molecule and gel-forming property due to which the drugs retain in the respiratory tract for a longer period of time providing enhanced therapeutic action of the drug. Chitosan-based nanomedicines would have the greatest effect when used to transport poor water soluble drugs, macromolecules like proteins, and peptides through the lungs. In this review, we highlight and discuss the role of chitosan and its nanomedicines in the treatment of chronic respiratory diseases such as pneumonia, asthma, COPD, lung cancer, tuberculosis, and COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Nanomedicine[MESH]
  • |*SARS-CoV-2[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Chitosan/*therapeutic use[MESH]
  • |Drug Carriers/*therapeutic use[MESH]


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