Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.ajhg.2021.05.017 http://scihub22266oqcxt.onion/10.1016/j.ajhg.2021.05.017 34115965!8173480!34115965     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Hum+Genet 2021 ; 108 (7): 1350-1355 Nephropedia Template TP {{tp|p=34115965|t=2021. Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals |pdf=|usr=}}{{34115965}} gab.com Text Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals JO: Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=34115965 #FOAvip Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, and results are publicly available through the Regeneron Genetics Center COVID-19 Results Browser. Twit Text FOAVip Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals ????Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=34115965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34115965 #FOAvip English Wikipedia <ref>{{Cite pmid|34115965}}</ref> Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals #MMPMID34115965 Kosmicki JA; Horowitz JE; Banerjee N; Lanche R; Marcketta A; Maxwell E; Bai X; Sun D; Backman JD; Sharma D; Kury FSP; Kang HM; O'Dushlaine C; Yadav A; Mansfield AJ; Li AH; Watanabe K; Gurski L; McCarthy SE; Locke AE; Khalid S; O'Keeffe S; Mbatchou J; Chazara O; Huang Y; Kvikstad E; O'Neill A; Nioi P; Parker MM; Petrovski S; Runz H; Szustakowski JD; Wang Q; Wong E; Cordova-Palomera A; Smith EN; Szalma S; Zheng X; Esmaeeli S; Davis JW; Lai YP; Chen X; Justice AE; Leader JB; Mirshahi T; Carey DJ; Verma A; Sirugo G; Ritchie MD; Rader DJ; Povysil G; Goldstein DB; Kiryluk K; Pairo-Castineira E; Rawlik K; Pasko D; Walker S; Meynert A; Kousathanas A; Moutsianas L; Tenesa A; Caulfield M; Scott R; Wilson JF; Baillie JK; Butler-Laporte G; Nakanishi T; Lathrop M; Richards JB; Jones M; Balasubramanian S; Salerno W; Shuldiner AR; Marchini J; Overton JD; Habegger L; Cantor MN; Reid JG; Baras A; Abecasis GR; Ferreira MAR Am J Hum Genet 2021[Jul]; 108 (7): 1350-1355 PMID34115965show ga Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, and results are publicly available through the Regeneron Genetics Center COVID-19 Results Browser. |*Exome Sequencing[MESH] |*Genetic Predisposition to Disease[MESH] |COVID-19/*diagnosis/*genetics/immunology/therapy[MESH] |Exome/*genetics[MESH] |Female[MESH] |Hospitalization/*statistics & numerical data[MESH] |Humans[MESH] |Interferons/genetics[MESH] |Male[MESH] |Prognosis[MESH] |SARS-CoV-2[MESH]Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 5(epmc).pdf DeepDyve Pubget Overpricing