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10.1016/j.immuni.2021.05.004 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.05.004 34115964!8189765!34115964     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (7): 1463-1477.e11 Nephropedia Template TP {{tp|p=34115964|t=2021. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation |pdf=|usr=}}{{34115964}} gab.com Text Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=34115964 #FOAvip Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1beta production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. By targeting electron transport chain complex 1 and independently of AMP-activated protein kinase (AMPK) or NF-kappaB, metformin blocked LPS-induced and ATP-dependent mitochondrial (mt) DNA synthesis and generation of oxidized mtDNA, an NLRP3 ligand. Myeloid-specific ablation of LPS-induced cytidine monophosphate kinase 2 (CMPK2), which is rate limiting for mtDNA synthesis, reduced ARDS severity without a direct effect on IL-6. Thus, inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration. Twit Text FOAVip Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=34115964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34115964 #FOAvip English Wikipedia <ref>{{Cite pmid|34115964}}</ref> Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation #MMPMID34115964 Xian H; Liu Y; Rundberg Nilsson A; Gatchalian R; Crother TR; Tourtellotte WG; Zhang Y; Aleman-Muench GR; Lewis G; Chen W; Kang S; Luevanos M; Trudler D; Lipton SA; Soroosh P; Teijaro J; de la Torre JC; Arditi M; Karin M; Sanchez-Lopez E Immunity 2021[Jul]; 54 (7): 1463-1477.e11 PMID34115964show ga Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1beta production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. By targeting electron transport chain complex 1 and independently of AMP-activated protein kinase (AMPK) or NF-kappaB, metformin blocked LPS-induced and ATP-dependent mitochondrial (mt) DNA synthesis and generation of oxidized mtDNA, an NLRP3 ligand. Myeloid-specific ablation of LPS-induced cytidine monophosphate kinase 2 (CMPK2), which is rate limiting for mtDNA synthesis, reduced ARDS severity without a direct effect on IL-6. Thus, inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration. |Adenosine Triphosphate/*metabolism[MESH] |Animals[MESH] |COVID-19/metabolism/prevention & control[MESH] |Cytokines/genetics/metabolism[MESH] |DNA, Mitochondrial/*biosynthesis/metabolism[MESH] |Humans[MESH] |Inflammasomes/*drug effects/metabolism[MESH] |Interleukin-1beta/genetics/metabolism[MESH] |Lipopolysaccharides/toxicity[MESH] |Metformin/*pharmacology/therapeutic use[MESH] |Mice[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism[MESH] |Nucleoside-Phosphate Kinase/metabolism[MESH] |Pneumonia/metabolism/*prevention & control[MESH] |Respiratory Distress Syndrome/chemically induced/prevention & control[MESH]Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates (epmc).pdf DeepDyve Pubget Overpricing