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10.1371/journal.pone.0251159

http://scihub22266oqcxt.onion/10.1371/journal.pone.0251159
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34115768!8195379!34115768
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suck abstract from ncbi


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pmid34115768      PLoS+One 2021 ; 16 (6): e0251159
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  • Longitudinal changes in IgG levels among COVID-19 recovered patients: A prospective cohort study #MMPMID34115768
  • Alzaabi AH; Ahmed LA; Rabooy AE; Zaabi AA; Alkaabi M; AlMahmoud F; Hamed MF; Bashaeb KO; Bakhsh AR; Adil S; Elmajed N; Abousalha AN; Uwaydah AK; Mazrouei KA
  • PLoS One 2021[]; 16 (6): e0251159 PMID34115768show ga
  • OBJECTIVES: To quantify SARS-CoV2 IgG antibody titers over time and assess the longevity of the immune response in a multi-ethnic population setting. SETTING: This prospective study was conducted in a tertiary hospital in Abu Dhabi city, UAE, among COVID-19 confirmed patients. The virus-specific IgG were measured quantitatively in serum samples from the patients during three visits over a period of 6 months. Serum IgG levels >/=15 AU/ml was used to define a positive response. PARTICIPANTS: 113 patients were analyzed at first visit, with a mean (SD) age of participants of 45.9 (11.8) years 87.5% of the patients were men. 63 and 27 participants had data available for visits 2 and 3, respectively. PRIMARY OUTCOME: Change in SARS-CoV2 IgG antibody titers over the visits. RESULTS: No mortality or re-infection were reported. 69% of the patients developed positive IgG response within the first month after the onset of symptoms. The levels of IgG showed a consistent increase during the first three months with a peak level during the third month. Increasing trend in the levels of IgG were observed in 82.5%, 55.6% and 70.4% of patients between visit 1 to visit 2, visit 2 to visit 3, and from visit 1 to visit 3, respectively. Furthermore, about 64.3% of the patients showed sustained increase in IgG response for more than 120 days. CONCLUSIONS: Our study indicates a sustained and prolonged positive immune response in COVID-19 recovered patients. The consistent rise in antibody and positive levels of IgG titers within the first 5 months suggest that immunization is possible, and the chances of reinfection minimal.
  • |Adult[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19/*blood/*epidemiology/virology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Hospitals, Military[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]
  • |RNA, Viral/genetics/isolation & purification[MESH]
  • |SARS-CoV-2/genetics/*immunology[MESH]
  • |Tertiary Care Centers[MESH]
  • |United Arab Emirates/epidemiology[MESH]


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