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suck abstract from ncbi


10.18632/aging.203181

http://scihub22266oqcxt.onion/10.18632/aging.203181
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34115612!8221359!34115612
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suck abstract from ncbi

pmid34115612      Aging+(Albany+NY) 2021 ; 13 (11): 14552-14556
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  • The key role of the level of ACE2 gene expression in SARS-CoV-2 infection #MMPMID34115612
  • Lecarpentier Y; Vallee A
  • Aging (Albany NY) 2021[Jun]; 13 (11): 14552-14556 PMID34115612show ga
  • SARS-CoV-2 more readily affects the elderly, especially as they present co-morbidities. In the COVID-19 pathogeny, ACE2 appears to be the key cell receptor for SARS-CoV-2 to infect humans. The level of ACE2 gene expression influences the susceptibility of contracting SARS-CoV-2. In circumstances in which the ACE2 level is low, the incidence of Covid-19 seems to be fewer. Two clinical patterns illustrate this observation, i. e., in infants and in Alzheimer's disease (AD). Very young children and AD patients get little COVID-19, in part probably due to decreased expression of ACE2. The determination of the nasal level of ACE2 gene expression could provide a useful scale to predict the susceptibility to contract the SARS-CoV-2 infection.
  • |Alzheimer Disease/complications/metabolism[MESH]
  • |Angiotensin-Converting Enzyme 2/*metabolism[MESH]
  • |COVID-19/*etiology/metabolism[MESH]
  • |Cerebrum/metabolism[MESH]
  • |Disease Susceptibility[MESH]
  • |Gene Expression[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Nasal Mucosa/metabolism[MESH]


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