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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Immunol 2021 ; 12 (ä): 674279 Nephropedia Template TP
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A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 #MMPMID34113347
Yeo JG; Leong JY; Tay SH; Nadua KD; Anderson DE; Lim AJM; Ng XW; Poh SL; Guo D; Yaung KN; Kumar P; Wasser M; Hazirah SN; Sutamam N; Chua CJH; Qui M; Foo R; Gamage AM; Yeo KT; Ramakrishna L; Arkachaisri T; Young BE; Lye DC; Wang LF; Chong CY; Tan NWH; Li J; Kam KQ; Ginhoux F; Thoon KC; Chan JKY; Yung CF; Albani S
Front Immunol 2021[]; 12 (ä): 674279 PMID34113347show ga
An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T(eff)) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T(reg)) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNgamma(+) memory CD4(+) T cells and virus-specific follicular helper T (T(FH)) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection.