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10.3389/fimmu.2021.674279

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.674279
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34113347!8185226!34113347
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suck abstract from ncbi


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pmid34113347      Front+Immunol 2021 ; 12 (ä): 674279
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  • A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19 #MMPMID34113347
  • Yeo JG; Leong JY; Tay SH; Nadua KD; Anderson DE; Lim AJM; Ng XW; Poh SL; Guo D; Yaung KN; Kumar P; Wasser M; Hazirah SN; Sutamam N; Chua CJH; Qui M; Foo R; Gamage AM; Yeo KT; Ramakrishna L; Arkachaisri T; Young BE; Lye DC; Wang LF; Chong CY; Tan NWH; Li J; Kam KQ; Ginhoux F; Thoon KC; Chan JKY; Yung CF; Albani S
  • Front Immunol 2021[]; 12 (ä): 674279 PMID34113347show ga
  • An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T(eff)) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T(reg)) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNgamma(+) memory CD4(+) T cells and virus-specific follicular helper T (T(FH)) cells. Overall, these findings pinpoint critical immune effector and regulatory mechanisms essential for a potent, yet harmless resolution of COVID-19 infection.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |CD4-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19/*immunology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |SARS-CoV-2/*immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]
  • |T Follicular Helper Cells/immunology[MESH]
  • |T-Lymphocytes, Regulatory/immunology[MESH]


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