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10.1038/s42003-021-02265-0 http://scihub22266oqcxt.onion/10.1038/s42003-021-02265-0 34112887!8192748!34112887     free     free     free       Commun+Biol 2021 ; 4 (1): 715 Nephropedia Template TP {{tp|p=34112887|t=2021. I(nsp1)ecting SARS-CoV-2-ribosome interactions |pdf=|usr=}}{{34112887}} gab.com Text I(nsp1)ecting SARS-CoV-2-ribosome interactions JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34112887 #FOAvip While SARS-CoV-2 is causing modern human history's most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), binds human ribosomes to inhibit host cell translation. Here, we examine the main conclusions on the molecular activity of Nsp1 and its role in suppressing innate immune responses. We discuss different scenarios potentially explaining how the viral RNA can bypass its own translation blockage and speculate on the suitability of Nsp1 as a therapeutic target. Twit Text FOAVip I(nsp1)ecting SARS-CoV-2-ribosome interactions ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34112887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34112887 #FOAvip English Wikipedia <ref>{{Cite pmid|34112887}}</ref> I(nsp1)ecting SARS-CoV-2-ribosome interactions #MMPMID34112887 Simeoni M; Cavinato T; Rodriguez D; Gatfield D Commun Biol 2021[Jun]; 4 (1): 715 PMID34112887show ga While SARS-CoV-2 is causing modern human history's most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), binds human ribosomes to inhibit host cell translation. Here, we examine the main conclusions on the molecular activity of Nsp1 and its role in suppressing innate immune responses. We discuss different scenarios potentially explaining how the viral RNA can bypass its own translation blockage and speculate on the suitability of Nsp1 as a therapeutic target. |5' Untranslated Regions[MESH] |Gene Expression Regulation, Viral[MESH] |Host-Pathogen Interactions/*physiology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Protein Biosynthesis[MESH] |RNA, Messenger/metabolism[MESH] |Ribosomes/metabolism/*virology[MESH] |SARS-CoV-2/genetics/*pathogenicity[MESH]I(nsp1)ecting SARS-CoV-2-ribosome interactions (epmc).pdf DeepDyve Pubget Overpricing