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10.1038/s41598-021-91625-1 http://scihub22266oqcxt.onion/10.1038/s41598-021-91625-1 34112877!8192542!34112877     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 12310 Nephropedia Template TP {{tp|p=34112877|t=2021. Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 |pdf=|usr=}}{{34112877}} gab.com Text Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34112877 #FOAvip The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or generate lists of differentially expressed genes between control and SARS-CoV-2-infected samples. Using a rank-based pattern matching strategy based on the Kolmogorov-Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). We validated 16 of our top predicted hits in live SARS-CoV-2 antiviral assays in either Calu-3 or 293T-ACE2 cells. Validation experiments in human cell lines showed that 11 of the 16 compounds tested to date (including clofazimine, haloperidol and others) had measurable antiviral activity against SARS-CoV-2. These initial results are encouraging as we continue to work towards a further analysis of these predicted drugs as potential therapeutics for the treatment of COVID-19. Twit Text FOAVip Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34112877 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34112877 #FOAvip English Wikipedia <ref>{{Cite pmid|34112877}}</ref> Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19 #MMPMID34112877 Le BL; Andreoletti G; Oskotsky T; Vallejo-Gracia A; Rosales R; Yu K; Kosti I; Leon KE; Bunis DG; Li C; Kumar GR; White KM; Garcia-Sastre A; Ott M; Sirota M Sci Rep 2021[Jun]; 11 (1): 12310 PMID34112877show ga The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or generate lists of differentially expressed genes between control and SARS-CoV-2-infected samples. Using a rank-based pattern matching strategy based on the Kolmogorov-Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). We validated 16 of our top predicted hits in live SARS-CoV-2 antiviral assays in either Calu-3 or 293T-ACE2 cells. Validation experiments in human cell lines showed that 11 of the 16 compounds tested to date (including clofazimine, haloperidol and others) had measurable antiviral activity against SARS-CoV-2. These initial results are encouraging as we continue to work towards a further analysis of these predicted drugs as potential therapeutics for the treatment of COVID-19. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19/genetics[MESH] |Computational Biology/methods[MESH] |Drug Repositioning/*methods[MESH] |Humans[MESH] |SARS-CoV-2/*drug effects/physiology[MESH]Transcriptomics-based drug repositioning pipeline identifies therapeut(epmc).pdf DeepDyve Pubget Overpricing