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10.1038/s41467-021-23886-3 http://scihub22266oqcxt.onion/10.1038/s41467-021-23886-3 34112801!8192507!34112801     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3534 Nephropedia Template TP {{tp|p=34112801|t=2021. Viral infiltration of pancreatic islets in patients with COVID-19 |pdf=|usr=}}{{34112801}} gab.com Text Viral infiltration of pancreatic islets in patients with COVID-19 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34112801 #FOAvip Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onset hyperglycemia and complications of preexisting diabetes have been observed in COVID-19 patients. Here, we performed a comprehensive analysis of pancreatic autopsy tissue from COVID-19 patients using immunofluorescence, immunohistochemistry, RNA scope and electron microscopy and detected SARS-CoV-2 viral infiltration of beta-cells in all patients. Using SARS-CoV-2 pseudoviruses, we confirmed that isolated human islet cells are permissive to infection. In eleven COVID-19 patients, we examined the expression of ACE2, TMPRSS and other receptors and factors, such as DPP4, HMBG1 and NRP1, that might facilitate virus entry. Whereas 70% of the COVID-19 patients expressed ACE2 in the vasculature, only 30% displayed ACE2-expression in beta-cells. Even in the absence of manifest new-onset diabetes, necroptotic cell death, immune cell infiltration and SARS-CoV-2 viral infection of pancreatic beta-cells may contribute to varying degrees of metabolic dysregulation in patients with COVID-19. Twit Text FOAVip Viral infiltration of pancreatic islets in patients with COVID-19 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34112801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34112801 #FOAvip English Wikipedia <ref>{{Cite pmid|34112801}}</ref> Viral infiltration of pancreatic islets in patients with COVID-19 #MMPMID34112801 Steenblock C; Richter S; Berger I; Barovic M; Schmid J; Schubert U; Jarzebska N; von Massenhausen A; Linkermann A; Schurmann A; Pablik J; Dienemann T; Evert K; Rodionov RN; Semenova NY; Zinserling VA; Gainetdinov RR; Baretton G; Lindemann D; Solimena M; Ludwig B; Bornstein SR Nat Commun 2021[Jun]; 12 (1): 3534 PMID34112801show ga Metabolic diseases are associated with an increased risk of severe COVID-19 and conversely, new-onset hyperglycemia and complications of preexisting diabetes have been observed in COVID-19 patients. Here, we performed a comprehensive analysis of pancreatic autopsy tissue from COVID-19 patients using immunofluorescence, immunohistochemistry, RNA scope and electron microscopy and detected SARS-CoV-2 viral infiltration of beta-cells in all patients. Using SARS-CoV-2 pseudoviruses, we confirmed that isolated human islet cells are permissive to infection. In eleven COVID-19 patients, we examined the expression of ACE2, TMPRSS and other receptors and factors, such as DPP4, HMBG1 and NRP1, that might facilitate virus entry. Whereas 70% of the COVID-19 patients expressed ACE2 in the vasculature, only 30% displayed ACE2-expression in beta-cells. Even in the absence of manifest new-onset diabetes, necroptotic cell death, immune cell infiltration and SARS-CoV-2 viral infection of pancreatic beta-cells may contribute to varying degrees of metabolic dysregulation in patients with COVID-19. |Adult[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Autopsy[MESH] |COVID-19/*pathology[MESH] |Diabetes Complications/pathology/virology[MESH] |Diabetes Mellitus/pathology[MESH] |Dipeptidyl Peptidase 4/metabolism[MESH] |Female[MESH] |HMGN Proteins/metabolism[MESH] |Humans[MESH] |Insulin-Secreting Cells/metabolism/*virology[MESH] |Male[MESH] |Middle Aged[MESH] |Neuropilin-1/metabolism[MESH] |Organ Specificity/physiology[MESH] |Receptors, Coronavirus/*metabolism[MESH] |SARS-CoV-2/*isolation & purification[MESH]Viral infiltration of pancreatic islets in patients with COVID-19 (epmc).pdf DeepDyve Pubget Overpricing