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10.1038/s41467-021-23683-y http://scihub22266oqcxt.onion/10.1038/s41467-021-23683-y 34112781!8192512!34112781     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3519 Nephropedia Template TP {{tp|p=34112781|t=2021. TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection |pdf=|usr=}}{{34112781}} gab.com Text TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34112781 #FOAvip TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR4 signal-mediated innate immune response remains unclear. Here we show that TLR4 signalling augments macrophage bactericidal activity through the mechanical sensor Piezo1. Bacterial infection or LPS stimulation triggers assembly of the complex of Piezo1 and TLR4 to remodel F-actin organization and augment phagocytosis, mitochondrion-phagosomal ROS production and bacterial clearance and genetic deficiency of Piezo1 results in abrogation of these responses. Mechanistically, LPS stimulates TLR4 to induce Piezo1-mediated calcium influx and consequently activates CaMKII-Mst1/2-Rac axis for pathogen ingestion and killing. Inhibition of CaMKII or knockout of either Mst1/2 or Rac1 results in reduced macrophage bactericidal activity, phenocopying the Piezo1 deficiency. Thus, we conclude that TLR4 drives the innate immune response via Piezo1 providing critical insight for understanding macrophage mechanophysiology and the host response. Twit Text FOAVip TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34112781 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34112781 #FOAvip English Wikipedia <ref>{{Cite pmid|34112781}}</ref> TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection #MMPMID34112781 Geng J; Shi Y; Zhang J; Yang B; Wang P; Yuan W; Zhao H; Li J; Qin F; Hong L; Xie C; Deng X; Sun Y; Wu C; Chen L; Zhou D Nat Commun 2021[Jun]; 12 (1): 3519 PMID34112781show ga TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors. However, the impact of mechanical sensing signals on TLR4 signal-mediated innate immune response remains unclear. Here we show that TLR4 signalling augments macrophage bactericidal activity through the mechanical sensor Piezo1. Bacterial infection or LPS stimulation triggers assembly of the complex of Piezo1 and TLR4 to remodel F-actin organization and augment phagocytosis, mitochondrion-phagosomal ROS production and bacterial clearance and genetic deficiency of Piezo1 results in abrogation of these responses. Mechanistically, LPS stimulates TLR4 to induce Piezo1-mediated calcium influx and consequently activates CaMKII-Mst1/2-Rac axis for pathogen ingestion and killing. Inhibition of CaMKII or knockout of either Mst1/2 or Rac1 results in reduced macrophage bactericidal activity, phenocopying the Piezo1 deficiency. Thus, we conclude that TLR4 drives the innate immune response via Piezo1 providing critical insight for understanding macrophage mechanophysiology and the host response. |*Immunity, Innate[MESH] |Actins/metabolism[MESH] |Animals[MESH] |Bacterial Infections/*immunology[MESH] |Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism[MESH] |Calcium/metabolism[MESH] |Cytoskeleton/genetics/metabolism[MESH] |Escherichia coli Infections/immunology[MESH] |Fluorescence Resonance Energy Transfer[MESH] |HEK293 Cells[MESH] |Hepatocyte Growth Factor/genetics/metabolism[MESH] |Humans[MESH] |Ion Channels/genetics/*metabolism[MESH] |Lipopolysaccharides/pharmacology[MESH] |Macrophages/*immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Neuropeptides/genetics/metabolism[MESH] |Phagocytosis/immunology[MESH] |Phagosomes/immunology/*metabolism[MESH] |Protein Serine-Threonine Kinases/genetics/metabolism[MESH] |Proto-Oncogene Proteins/genetics/metabolism[MESH] |Reactive Oxygen Species/metabolism[MESH] |Serine-Threonine Kinase 3[MESH] |Signal Transduction/genetics/immunology[MESH] |Toll-Like Receptor 4/immunology/*metabolism[MESH]TLR4 signalling via Piezo1 engages and enhances the macrophage mediate(epmc).pdf DeepDyve Pubget Overpricing