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10.1007/s11010-021-04204-3

http://scihub22266oqcxt.onion/10.1007/s11010-021-04204-3
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34110554!8190527!34110554
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suck abstract from ncbi


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pmid34110554      Mol+Cell+Biochem 2021 ; 476 (10): 3815-3825
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  • Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation #MMPMID34110554
  • Perez-Campos Mayoral L; Hernandez-Huerta MT; Papy-Garcia D; Barritault D; Zenteno E; Sanchez Navarro LM; Perez-Campos Mayoral E; Matias Cervantes CA; Martinez Cruz M; Mayoral Andrade G; Lopez Cervantes M; Vazquez Martinez G; Lopez Sanchez C; Pina Canseco S; Martinez Cruz R; Perez-Campos E
  • Mol Cell Biochem 2021[Oct]; 476 (10): 3815-3825 PMID34110554show ga
  • Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.
  • |Anticoagulants/*therapeutic use[MESH]
  • |Blood Platelets/immunology[MESH]
  • |COVID-19/immunology/*pathology[MESH]
  • |Chagas Disease/immunology/*pathology[MESH]
  • |Complement Activation/immunology[MESH]
  • |Endothelium/pathology[MESH]
  • |Heparitin Sulfate/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Pathogen-Associated Molecular Pattern Molecules/immunology[MESH]
  • |Platelet Activation/immunology[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Thrombosis/*drug therapy/*pathology[MESH]


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