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10.1021/jacs.1c02664 http://scihub22266oqcxt.onion/10.1021/jacs.1c02664 34110141!ä!34110141 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2021 ; 143 (24): 8957-8961 Nephropedia Template TP {{tp|p=34110141|t=2021. REVEALR: A Multicomponent XNAzyme-Based Nucleic Acid Detection System for SARS-CoV-2 |pdf=|usr=}}{{34110141}} gab.com Text REVEALR: A Multicomponent XNAzyme-Based Nucleic Acid Detection System for SARS-CoV-2 JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=34110141 #FOAvip Isothermal amplification strategies capable of rapid, inexpensive, and accurate nucleic acid detection provide new options for large-scale pathogen detection, disease diagnosis, and genotyping. Here we report a highly sensitive multicomponent XNA-based nucleic acid detection platform that combines analyte preamplification with X10-23-mediated catalysis to detect the viral pathogen responsible for COVID-19. The platform, termed RNA-Encoded Viral Nucleic Acid Analyte Reporter (REVEALR), functions with a detection limit of </=20 aM ( approximately 10 copies/muL) using conventional fluorescence and paper-based lateral flow readout modalities. With a total assay time of 1 h, REVEALR provides a convenient nucleic acid alternative to equivalent CRISPR-based approaches, which have become popular methods for SARS-CoV-2 detection. The assay shows no cross-reactivity for other in vitro transcribed respiratory viral RNAs and functions with perfect accuracy against COVID-19 patient-derived clinical samples. Twit Text FOAVip REVEALR: A Multicomponent XNAzyme-Based Nucleic Acid Detection System for SARS-CoV-2 ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=34110141 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34110141 #FOAvip English Wikipedia <ref>{{Cite pmid|34110141}}</ref> REVEALR: A Multicomponent XNAzyme-Based Nucleic Acid Detection System for SARS-CoV-2 #MMPMID34110141 Yang K; Chaput JC J Am Chem Soc 2021[Jun]; 143 (24): 8957-8961 PMID34110141show ga Isothermal amplification strategies capable of rapid, inexpensive, and accurate nucleic acid detection provide new options for large-scale pathogen detection, disease diagnosis, and genotyping. Here we report a highly sensitive multicomponent XNA-based nucleic acid detection platform that combines analyte preamplification with X10-23-mediated catalysis to detect the viral pathogen responsible for COVID-19. The platform, termed RNA-Encoded Viral Nucleic Acid Analyte Reporter (REVEALR), functions with a detection limit of |Animals[MESH] |COVID-19 Nucleic Acid Testing/instrumentation/*methods[MESH] |COVID-19/*diagnosis[MESH] |Chlorocebus aethiops[MESH] |DNA, Catalytic/*chemistry[MESH] |Female[MESH] |Humans[MESH] |Limit of Detection[MESH] |Male[MESH] |Nasopharynx/virology[MESH] |Nucleic Acid Amplification Techniques[MESH] |Oligodeoxyribonucleotides/chemistry[MESH] |Paper[MESH] |RNA, Viral/*analysis[MESH] |SARS-CoV-2/*chemistry[MESH] |Sensitivity and Specificity[MESH]REVEALR: A Multicomponent XNAzyme-Based Nucleic Acid Detection System (epmc).pdf DeepDyve Pubget Overpricing