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10.1016/j.csbj.2021.05.054 http://scihub22266oqcxt.onion/10.1016/j.csbj.2021.05.054 34109017!8178965!34109017     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Comput+Struct+Biotechnol+J 2021 ; 19 (ä): 3864-3875 Nephropedia Template TP {{tp|p=34109017|t=2021. The evolving proteome of SARS-CoV-2 predominantly uses mutation combination strategy for survival |pdf=|usr=}}{{34109017}} gab.com Text The evolving proteome of SARS-CoV-2 predominantly uses mutation combination strategy for survival JO: Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=34109017 #FOAvip The knowledge about SARS-CoV-2 proteome variations is important to understand its evolutionary tactics and in drug/vaccine design. An extensive analysis of 125,747 whole proteome reveals 7915 recurring mutations (involving 5146 positions) during December2019-November 2020. Among these, 10 and 51 are highly and moderately recurring mutations respectively. Ever since the pandemic outbreak, approximately 50% new proteome variants evolve every month, resulting in 5 major clades. Intriguingly, approximately 70% of the variants reported in January 2020 are due to the emergence of new mutations, which sharply declines to? approximately ?40% in April 2020 and thenceforth, declines steadily till November 2020( approximately 10%). An exactly opposite trend is seen for variants evolved with cocktail of existing mutations: the lowest in January 2020( approximately 20%) and the highest in November 2020(80%). This leads to a steady increase in the average number of mutations per sequence. This indicates that the virus has reached the slow pace to accept new mutations. Instead, it uses a mutation combination strategy for survival. Twit Text FOAVip The evolving proteome of SARS-CoV-2 predominantly uses mutation combination strategy for survival ????Comput Struct Biotechnol J http://www.kidney.de/pget.php?&tw=1&pmid=34109017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34109017 #FOAvip English Wikipedia <ref>{{Cite pmid|34109017}}</ref> The evolving proteome of SARS-CoV-2 predominantly uses mutation combination strategy for survival #MMPMID34109017 Patro LPP; Sathyaseelan C; Uttamrao PP; Rathinavelan T Comput Struct Biotechnol J 2021[]; 19 (ä): 3864-3875 PMID34109017show ga The knowledge about SARS-CoV-2 proteome variations is important to understand its evolutionary tactics and in drug/vaccine design. An extensive analysis of 125,747 whole proteome reveals 7915 recurring mutations (involving 5146 positions) during December2019-November 2020. Among these, 10 and 51 are highly and moderately recurring mutations respectively. Ever since the pandemic outbreak, approximately 50% new proteome variants evolve every month, resulting in 5 major clades. Intriguingly, approximately 70% of the variants reported in January 2020 are due to the emergence of new mutations, which sharply declines to? approximately ?40% in April 2020 and thenceforth, declines steadily till November 2020( approximately 10%). An exactly opposite trend is seen for variants evolved with cocktail of existing mutations: the lowest in January 2020( approximately 20%) and the highest in November 2020(80%). This leads to a steady increase in the average number of mutations per sequence. This indicates that the virus has reached the slow pace to accept new mutations. Instead, it uses a mutation combination strategy for survival. äThe evolving proteome of SARS-CoV-2 predominantly uses mutation combin(epmc).pdf DeepDyve Pubget Overpricing