Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.3389/fimmu.2021.665773

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.665773
suck pdf from google scholar
34108966!8181441!34108966
unlimited free pdf from europmc34108966    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid34108966      Front+Immunol 2021 ; 12 (ä): 665773
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Transcriptional Changes in CD16+ Monocytes May Contribute to the Pathogenesis of COVID-19 #MMPMID34108966
  • Chilunda V; Martinez-Aguado P; Xia LC; Cheney L; Murphy A; Veksler V; Ruiz V; Calderon TM; Berman JW
  • Front Immunol 2021[]; 12 (ä): 665773 PMID34108966show ga
  • The COVID-19 pandemic has caused more than three million deaths globally. The severity of the disease is characterized, in part, by a dysregulated immune response. CD16+ monocytes are innate immune cells involved in inflammatory responses to viral infections, and tissue repair, among other functions. We characterized the transcriptional changes in CD16+ monocytes from PBMC of people with COVID-19, and from healthy individuals using publicly available single cell RNA sequencing data. CD16+ monocytes from people with COVID-19 compared to those from healthy individuals expressed transcriptional changes indicative of increased cell activation, and induction of a migratory phenotype. We also analyzed COVID-19 cases based on severity of the disease and found that mild cases were characterized by upregulation of interferon response and MHC class II related genes, whereas the severe cases had dysregulated expression of mitochondrial and antigen presentation genes, and upregulated inflammatory, cell movement, and apoptotic gene signatures. These results suggest that CD16+ monocytes in people with COVID-19 contribute to a dysregulated host response characterized by decreased antigen presentation, and an elevated inflammatory response with increased monocytic infiltration into tissues. Our results show that there are transcriptomic changes in CD16+ monocytes that may impact the functions of these cells, contributing to the pathogenesis and severity of COVID-19.
  • |*Transcription, Genetic[MESH]
  • |*Transcriptome[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Apoptosis Regulatory Proteins/genetics/metabolism[MESH]
  • |COVID-19/genetics/immunology/metabolism/*virology[MESH]
  • |Case-Control Studies[MESH]
  • |Cytokines/genetics/metabolism[MESH]
  • |Female[MESH]
  • |GPI-Linked Proteins/metabolism[MESH]
  • |Gene Expression Profiling[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Inflammation Mediators/metabolism[MESH]
  • |Interferon Regulatory Factors/genetics/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Mitochondrial Proteins/genetics/metabolism[MESH]
  • |Monocytes/immunology/metabolism/*virology[MESH]
  • |RNA-Seq[MESH]
  • |Receptors, IgG/*metabolism[MESH]
  • |SARS-CoV-2/immunology/*pathogenicity[MESH]
  • |Severity of Illness Index[MESH]
  • |Single-Cell Analysis[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box