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10.1038/s41556-021-00690-1 http://scihub22266oqcxt.onion/10.1038/s41556-021-00690-1 34108657!9105401!34108657     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34108657&cmd=llinks): Failed to open stream: HTTP request failed! 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Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19 |pdf=|usr=}}{{34108657}} gab.com Text Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19 JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34108657 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes severe complications and even death. However, asymptomatic infection has also been reported, highlighting the difference in immune responses among individuals. Here we performed single-cell chromatin accessibility and T cell-receptor analyses of peripheral blood mononuclear cells collected from individuals convalescing from COVID-19 and healthy donors. Chromatin remodelling was observed in both innate and adaptive immune cells in the individuals convalescing from COVID-19. Compared with healthy donors, recovered individuals contained abundant TBET-enriched CD16(+) and IRF1-enriched CD14(+) monocytes with sequential trained and activated epigenomic states. The B-cell lineage in recovered individuals exhibited an accelerated developmental programme from immature B cells to antibody-producing plasma cells. Finally, an integrated analysis of single-cell T cell-receptor clonality with the chromatin accessibility landscape revealed the expansion of putative SARS-CoV-2-specific CD8(+) T cells with epigenomic profiles that promote the differentiation of effector or memory cells. Overall, our data suggest that immune cells of individuals convalescing from COVID-19 exhibit global remodelling of the chromatin accessibility landscape, indicative of the establishment of immunological memory. Twit Text FOAVip Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19 ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=34108657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34108657 #FOAvip English Wikipedia <ref>{{Cite pmid|34108657}}</ref> Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19 #MMPMID34108657 You M; Chen L; Zhang D; Zhao P; Chen Z; Qin EQ; Gao Y; Davis MM; Yang P Nat Cell Biol 2021[Jun]; 23 (6): 620-630 PMID34108657show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection often causes severe complications and even death. However, asymptomatic infection has also been reported, highlighting the difference in immune responses among individuals. Here we performed single-cell chromatin accessibility and T cell-receptor analyses of peripheral blood mononuclear cells collected from individuals convalescing from COVID-19 and healthy donors. Chromatin remodelling was observed in both innate and adaptive immune cells in the individuals convalescing from COVID-19. Compared with healthy donors, recovered individuals contained abundant TBET-enriched CD16(+) and IRF1-enriched CD14(+) monocytes with sequential trained and activated epigenomic states. The B-cell lineage in recovered individuals exhibited an accelerated developmental programme from immature B cells to antibody-producing plasma cells. Finally, an integrated analysis of single-cell T cell-receptor clonality with the chromatin accessibility landscape revealed the expansion of putative SARS-CoV-2-specific CD8(+) T cells with epigenomic profiles that promote the differentiation of effector or memory cells. Overall, our data suggest that immune cells of individuals convalescing from COVID-19 exhibit global remodelling of the chromatin accessibility landscape, indicative of the establishment of immunological memory. |*Epigenesis, Genetic[MESH] |*Epigenomics[MESH] |*Genes, T-Cell Receptor[MESH] |*Immunologic Memory[MESH] |*Single-Cell Analysis[MESH] |Adaptive Immunity[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |B-Lymphocytes/immunology/metabolism/virology[MESH] |CD8-Positive T-Lymphocytes/immunology/metabolism/virology[MESH] |COVID-19/*genetics/immunology/metabolism/virology[MESH] |Case-Control Studies[MESH] |Cell Differentiation[MESH] |Chromatin Assembly and Disassembly[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Lymphocyte Subsets/*immunology/metabolism/virology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/*immunology/metabolism/virology[MESH] |SARS-CoV-2/*immunology/pathogenicity[MESH]Single-cell epigenomic landscape of peripheral immune cells reveals es(epmc).pdf DeepDyve Pubget Overpricing