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10.1038/s41598-021-91754-7 http://scihub22266oqcxt.onion/10.1038/s41598-021-91754-7 34108608!8190311!34108608     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 12174 Nephropedia Template TP {{tp|p=34108608|t=2021. A single transcript for the prognosis of disease severity in COVID-19 patients |pdf=|usr=}}{{34108608}} gab.com Text A single transcript for the prognosis of disease severity in COVID-19 patients JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34108608 #FOAvip With many countries strapped for medical resources due to the COVID-19 pandemic, it is highly desirable to allocate the precious resources to those who need them the most. Several markers have been found to be associated with the disease severity in COVID-19 patients. However, the established markers only display modest prognostic power individually and better markers are urgently needed. The aim of this study is to investigate the potential of S100A12, a prominent marker gene for bacterial infection, in the prognosis of disease severity in COVID-19 patients. To ensure the robustness of the association, a total of 1695 samples from 14 independent transcriptome datasets on sepsis, influenza infection and COVID-19 infection were examined. First, it was demonstrated that S100A12 was a marker for sepsis and severity of sepsis. Then, S100A12 was found to be a marker for severe influenza infection, and there was an upward trend of S100A12 expression as the severity level of influenza infection increased. As for COVID-19 infection, it was found that S100A12 expression was elevated in patients with severe and critical COVID-19 infection. More importantly, S100A12 expression at hospital admission was robustly correlated with future quantitative indexes of disease severity and outcome in COVID-19 patients, superior to established prognostic markers including CRP, PCT, d-dimer, ferritin, LDH and fibrinogen. Thus, S100A12 is a valuable novel prognostic marker for COVID-19 severity and deserves more attention. Twit Text FOAVip A single transcript for the prognosis of disease severity in COVID-19 patients ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34108608 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34108608 #FOAvip English Wikipedia <ref>{{Cite pmid|34108608}}</ref> A single transcript for the prognosis of disease severity in COVID-19 patients #MMPMID34108608 Lei H Sci Rep 2021[Jun]; 11 (1): 12174 PMID34108608show ga With many countries strapped for medical resources due to the COVID-19 pandemic, it is highly desirable to allocate the precious resources to those who need them the most. Several markers have been found to be associated with the disease severity in COVID-19 patients. However, the established markers only display modest prognostic power individually and better markers are urgently needed. The aim of this study is to investigate the potential of S100A12, a prominent marker gene for bacterial infection, in the prognosis of disease severity in COVID-19 patients. To ensure the robustness of the association, a total of 1695 samples from 14 independent transcriptome datasets on sepsis, influenza infection and COVID-19 infection were examined. First, it was demonstrated that S100A12 was a marker for sepsis and severity of sepsis. Then, S100A12 was found to be a marker for severe influenza infection, and there was an upward trend of S100A12 expression as the severity level of influenza infection increased. As for COVID-19 infection, it was found that S100A12 expression was elevated in patients with severe and critical COVID-19 infection. More importantly, S100A12 expression at hospital admission was robustly correlated with future quantitative indexes of disease severity and outcome in COVID-19 patients, superior to established prognostic markers including CRP, PCT, d-dimer, ferritin, LDH and fibrinogen. Thus, S100A12 is a valuable novel prognostic marker for COVID-19 severity and deserves more attention. |*Gene Expression Regulation[MESH] |*Severity of Illness Index[MESH] |Adult[MESH] |COVID-19/*diagnosis/*genetics[MESH] |Female[MESH] |Genetic Markers/genetics[MESH] |Humans[MESH] |Influenza, Human/diagnosis/genetics[MESH] |Male[MESH] |Prognosis[MESH] |RNA, Messenger/genetics[MESH]A single transcript for the prognosis of disease severity in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing