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10.1038/s41467-021-23621-y http://scihub22266oqcxt.onion/10.1038/s41467-021-23621-y 34108465!8190301!34108465     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 3501 Nephropedia Template TP {{tp|p=34108465|t=2021. Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection |pdf=|usr=}}{{34108465}} gab.com Text Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34108465 #FOAvip The characteristics of COVID-19 patients with persistent SARS-CoV-2 infection are not yet well described. Here, we compare the clinical and molecular features of patients with long duration of viral shedding (LDs) with those from patients with short duration patients (SDs), and healthy donors (HDs). We find that several cytokines and chemokines, such as interleukin (IL)-2, tumor necrosis factor (TNF) and lymphotoxin alpha (LT-alpha) are present at lower levels in LDs than SDs. Single-cell RNA sequencing shows that natural killer (NK) cells and CD14(+) monocytes are reduced, while regulatory T cells are increased in LDs; moreover, T and NK cells in LDs are less activated than in SDs. Importantly, most cells in LDs show reduced expression of ribosomal protein (RP) genes and related pathways, with this inversed correlation between RP levels and infection duration further validated in 103 independent patients. Our results thus indicate that immunosuppression and low RP expression may be related to the persistence of the viral infection in COVID-19 patients. Twit Text FOAVip Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34108465 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34108465 #FOAvip English Wikipedia <ref>{{Cite pmid|34108465}}</ref> Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infection #MMPMID34108465 Yang B; Fan J; Huang J; Guo E; Fu Y; Liu S; Xiao R; Liu C; Lu F; Qin T; He C; Wang Z; Qin X; Hu D; You L; Li X; Wang T; Wu P; Chen G; Zhou J; Li K; Sun C Nat Commun 2021[Jun]; 12 (1): 3501 PMID34108465show ga The characteristics of COVID-19 patients with persistent SARS-CoV-2 infection are not yet well described. Here, we compare the clinical and molecular features of patients with long duration of viral shedding (LDs) with those from patients with short duration patients (SDs), and healthy donors (HDs). We find that several cytokines and chemokines, such as interleukin (IL)-2, tumor necrosis factor (TNF) and lymphotoxin alpha (LT-alpha) are present at lower levels in LDs than SDs. Single-cell RNA sequencing shows that natural killer (NK) cells and CD14(+) monocytes are reduced, while regulatory T cells are increased in LDs; moreover, T and NK cells in LDs are less activated than in SDs. Importantly, most cells in LDs show reduced expression of ribosomal protein (RP) genes and related pathways, with this inversed correlation between RP levels and infection duration further validated in 103 independent patients. Our results thus indicate that immunosuppression and low RP expression may be related to the persistence of the viral infection in COVID-19 patients. |B-Lymphocytes/metabolism/pathology[MESH] |COVID-19/*immunology/virology[MESH] |Cytokines/blood[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Killer Cells, Natural/metabolism/pathology[MESH] |Leukocytes, Mononuclear/pathology[MESH] |Lymphocyte Activation/genetics[MESH] |Lymphocyte Subsets/metabolism/pathology[MESH] |Ribosomal Proteins/genetics[MESH] |SARS-CoV-2/isolation & purification/*pathogenicity[MESH] |Signal Transduction/genetics[MESH] |T-Lymphocytes/metabolism/pathology[MESH]Clinical and molecular characteristics of COVID-19 patients with persi(epmc).pdf DeepDyve Pubget Overpricing