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10.1093/nar/gkab478

http://scihub22266oqcxt.onion/10.1093/nar/gkab478
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34107016!8344854!34107016
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suck abstract from ncbi


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pmid34107016      Nucleic+Acids+Res 2021 ; 49 (15): e90
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  • VirusViz: comparative analysis and effective visualization of viral nucleotide and amino acid variants #MMPMID34107016
  • Bernasconi A; Gulino A; Alfonsi T; Canakoglu A; Pinoli P; Sandionigi A; Ceri S
  • Nucleic Acids Res 2021[Sep]; 49 (15): e90 PMID34107016show ga
  • Variant visualization plays an important role in supporting the viral evolution analysis, extremely valuable during the COVID-19 pandemic. VirusViz is a web-based application for comparing variants of selected viral populations and their sub-populations; it is primarily focused on SARS-CoV-2 variants, although the tool also supports other viral species (SARS-CoV, MERS-CoV, Dengue, Ebola). As input, VirusViz imports results of queries extracting variants and metadata from the large database ViruSurf, which integrates information about most SARS-CoV-2 sequences publicly deposited worldwide. Moreover, VirusViz accepts sequences of new viral populations as multi-FASTA files plus corresponding metadata in CSV format; a bioinformatic pipeline builds a suitable input for VirusViz by extracting the nucleotide and amino acid variants. Pages of VirusViz provide metadata summarization, variant descriptions, and variant visualization with rich options for zooming, highlighting variants or regions of interest, and switching from nucleotides to amino acids; sequences can be grouped, groups can be comparatively analyzed. For SARS-CoV-2, we manually collect mutations with known or predicted levels of severity/virulence, as indicated in linked research articles; such critical mutations are reported when observed in sequences. The system includes light-weight project management for downloading, resuming, and merging data analysis sessions. VirusViz is freely available at http://gmql.eu/virusviz/.
  • |*Data Visualization[MESH]
  • |Amino Acid Sequence[MESH]
  • |Base Sequence[MESH]
  • |COVID-19/*virology[MESH]
  • |Databases, Factual[MESH]
  • |Humans[MESH]
  • |Knowledge Bases[MESH]
  • |SARS-CoV-2/*chemistry/classification/*genetics[MESH]
  • |South Africa/epidemiology[MESH]


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