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10.1016/j.jmii.2021.03.015

http://scihub22266oqcxt.onion/10.1016/j.jmii.2021.03.015
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34103263!8021444!34103263
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suck abstract from ncbi


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pmid34103263      J+Microbiol+Immunol+Infect 2021 ; 54 (5): 808-815
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  • Evaluation of superinfection, antimicrobial usage, and airway microbiome with metagenomic sequencing in COVID-19 patients: A cohort study in Shanghai #MMPMID34103263
  • Miao Q; Ma Y; Ling Y; Jin W; Su Y; Wang Q; Pan J; Zhang Y; Chen H; Yuan J; Wu H; Hu B
  • J Microbiol Immunol Infect 2021[Oct]; 54 (5): 808-815 PMID34103263show ga
  • BACKGROUND: In COVID-19 patients, information regarding superinfection, antimicrobial assessment, and the value of metagenomic sequencing (MS) could help develop antimicrobial stewardship. METHOD: This retrospective study analyzed 323 laboratory-confirmed COVID-19 patients for co-infection rate and antimicrobial usage in the Shanghai Public Health Clinical Center (SPHCC) from January 23rd to March 14th 2020. The microbiota composition was also investigated in patients with critically severe COVID-19. RESULTS: The total population co-infection rate was 17/323 (5.3%) and 0/229 (0), 4/78 (5.1%), and 13/16 (81.3%) for the mild, severe, and critically severe subgroups, respectively. Proven fungal infection was significantly associated with a higher mortality rate (p = 0.029). In critically severe patients, the rate of antimicrobials and carbapenem usage were 16/16 (100%) and 13/16 (81.3%), respectively, in which the preemptive and empiric antimicrobial days accounted for 51.6% and 30.1%, respectively. Targeted therapy only accounted for 18.3%. MS was implemented to detect non-COVID-19 virus co-existence and the semi-quantitative surveillance of bacteremia, with clear clinical benefit seen in cases with MS-based precision antimicrobial management. Airway microbiome analysis suggested that the microbiota compositions in critically severe COVID-19 patients were likely due to intubation and mechanical ventilation. CONCLUSIONS: In the SPHCC cohort, we observed a non-negligible rate of super-infection, especially for the critically ill COVID-19 patients. Fungal co-infection requires intensive attention due to the high risk of mortality, and the clinical benefit of MS in guiding antimicrobial management warrants further investigation.
  • |*COVID-19[MESH]
  • |*Metagenomics[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Anti-Bacterial Agents/*therapeutic use[MESH]
  • |Antimicrobial Stewardship[MESH]
  • |China[MESH]
  • |Cohort Studies[MESH]
  • |Coinfection/drug therapy[MESH]
  • |Critical Illness[MESH]
  • |Female[MESH]
  • |High-Throughput Nucleotide Sequencing[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Microbiota/genetics/*physiology[MESH]
  • |Middle Aged[MESH]
  • |Mycoses/drug therapy[MESH]
  • |Respiratory System/*microbiology[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]


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