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10.1172/JCI150175 http://scihub22266oqcxt.onion/10.1172/JCI150175 34101623!8279581!34101623     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2021 ; 131 (14): ä Nephropedia Template TP {{tp|p=34101623|t=2021. Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients |pdf=|usr=}}{{34101623}} gab.com Text Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34101623 #FOAvip Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2, with BNT162b2 (trade name: Comirnaty) efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine-induced immunity. We therefore comprehensively analyzed humoral and cellular responses in kidney transplant recipients after the standard second vaccination dose. As opposed to all healthy vaccinees and the majority of hemodialysis patients, only 4 of 39 and 1 of 39 transplanted individuals showed IgA and IgG seroconversion at day 8 +/- 1 after booster immunization, with minor changes until day 23 +/- 5, respectively. Although most transplanted patients mounted spike-specific T helper cell responses, frequencies were significantly reduced compared with those in controls and dialysis patients and this was accompanied by a broad impairment in effector cytokine production, memory differentiation, and activation-related signatures. Spike-specific CD8+ T cell responses were less abundant than their CD4+ counterparts in healthy controls and hemodialysis patients and almost undetectable in transplant patients. Promotion of anti-HLA antibodies or acute rejection was not detected after vaccination. In summary, our data strongly suggest revised vaccination approaches in immunosuppressed patients, including individual immune monitoring for protection of this vulnerable group at risk of developing severe COVID-19. Twit Text FOAVip Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=34101623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34101623 #FOAvip English Wikipedia <ref>{{Cite pmid|34101623}}</ref> Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients #MMPMID34101623 Sattler A; Schrezenmeier E; Weber UA; Potekhin A; Bachmann F; Straub-Hohenbleicher H; Budde K; Storz E; Pross V; Bergmann Y; Thole LM; Tizian C; Holsken O; Diefenbach A; Schrezenmeier H; Jahrsdorfer B; Zemojtel T; Jechow K; Conrad C; Lukassen S; Stauch D; Lachmann N; Choi M; Halleck F; Kotsch K J Clin Invest 2021[Jul]; 131 (14): ä PMID34101623show ga Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2, with BNT162b2 (trade name: Comirnaty) efficiently protecting individuals from COVID-19 across a broad age range. Still, it remains largely unknown how renal insufficiency and immunosuppressive medication affect development of vaccine-induced immunity. We therefore comprehensively analyzed humoral and cellular responses in kidney transplant recipients after the standard second vaccination dose. As opposed to all healthy vaccinees and the majority of hemodialysis patients, only 4 of 39 and 1 of 39 transplanted individuals showed IgA and IgG seroconversion at day 8 +/- 1 after booster immunization, with minor changes until day 23 +/- 5, respectively. Although most transplanted patients mounted spike-specific T helper cell responses, frequencies were significantly reduced compared with those in controls and dialysis patients and this was accompanied by a broad impairment in effector cytokine production, memory differentiation, and activation-related signatures. Spike-specific CD8+ T cell responses were less abundant than their CD4+ counterparts in healthy controls and hemodialysis patients and almost undetectable in transplant patients. Promotion of anti-HLA antibodies or acute rejection was not detected after vaccination. In summary, our data strongly suggest revised vaccination approaches in immunosuppressed patients, including individual immune monitoring for protection of this vulnerable group at risk of developing severe COVID-19. |*SARS-CoV-2/immunology[MESH] |Adult[MESH] |Aged[MESH] |Antibodies, Viral/biosynthesis[MESH] |BNT162 Vaccine[MESH] |COVID-19 Vaccines/*administration & dosage/immunology[MESH] |COVID-19/*immunology/*prevention & control[MESH] |Case-Control Studies[MESH] |Cohort Studies[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Cellular[MESH] |Immunity, Humoral[MESH] |Immunization, Secondary[MESH] |Immunoglobulin A/biosynthesis[MESH] |Immunoglobulin G/biosynthesis[MESH] |Immunologic Memory[MESH] |Immunosuppressive Agents/adverse effects[MESH] |Kidney Transplantation/*adverse effects[MESH] |Lymphocyte Activation[MESH] |Male[MESH] |Middle Aged[MESH] |Monitoring, Immunologic[MESH] |Renal Dialysis/adverse effects[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH] |T-Lymphocytes/immunology[MESH]Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozi(epmc).pdf DeepDyve Pubget Overpricing