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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Arch+Virol 2021 ; 166 (8): 2299-2303 Nephropedia Template TP
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Antibody response in COVID-19 patients with and without re-positive RT-PCR results during the convalescent phase #MMPMID34101005
Peng J; Liu ZY; Yu XJ; Chen XY; Zhang K; Liu Y; Su YY; Sun CQ
Arch Virol 2021[Aug]; 166 (8): 2299-2303 PMID34101005show ga
Nucleic acid testing and antibody testing data from 143 recovered COVID-19 patients during the convalescent phase were retrospectively analyzed. A total of 23 (16.1%) recovered patients re-tested positive for SARS-CoV-2 RNA by RT-PCR. Three months after symptom onset, 100% and 99.3% of the patients remained positive for total and IgG antibodies, and the antibody levels remained high. IgM antibodies declined rapidly, with a median time to seroconversion of 67 (95% CI: 59, 75) days after onset. Approximately 25% of patients were seronegative for IgA antibodies at three months after onset. There was no statistically significant difference in antibody kinetics between patients with and without re-positive RT-PCR results during the convalescent phase.