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10.1101/2021.05.31.21255594 http://scihub22266oqcxt.onion/10.1101/2021.05.31.21255594 34100020!8183010!34100020     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       medRxiv 2021 ; ä (ä): ä Nephropedia Template TP {{tp|p=34100020|t=2021. Signatures of mast cell activation are associated with severe COVID-19 |pdf=|usr=}}{{34100020}} gab.com Text Signatures of mast cell activation are associated with severe COVID-19 JO: medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34100020 #FOAvip Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in severely ill patients and the pathophysiology of disease is thought to be immune-mediated. Mast cells (MCs) are polyfunctional immune cells present in the airways, where they respond to certain viruses and allergens, often promoting inflammation. We observed widespread degranulation of MCs during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates. In humans, transcriptional changes in patients requiring oxygen supplementation also implicated cells with a MC phenotype. MC activation in humans was confirmed, through detection of the MC-specific protease, chymase, levels of which were significantly correlated with disease severity. These results support the association of MC activation with severe COVID-19, suggesting potential strategies for intervention. Twit Text FOAVip Signatures of mast cell activation are associated with severe COVID-19 ????medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=34100020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34100020 #FOAvip English Wikipedia <ref>{{Cite pmid|34100020}}</ref> Signatures of mast cell activation are associated with severe COVID-19 #MMPMID34100020 Tan J; Anderson DE; Rathore APS; O'Neill A; Mantri CK; Saron WAA; Lee C; Cui CW; Kang AEZ; Foo R; Kalimuddin S; Low JG; Ho L; Tambyah P; Burke TW; Woods CW; Chan KR; Karhausen J; John ALS medRxiv 2021[Jun]; ä (ä): ä PMID34100020show ga Lung inflammation is a hallmark of Coronavirus disease 2019 (COVID-19) in severely ill patients and the pathophysiology of disease is thought to be immune-mediated. Mast cells (MCs) are polyfunctional immune cells present in the airways, where they respond to certain viruses and allergens, often promoting inflammation. We observed widespread degranulation of MCs during acute and unresolved airway inflammation in SARS-CoV-2-infected mice and non-human primates. In humans, transcriptional changes in patients requiring oxygen supplementation also implicated cells with a MC phenotype. MC activation in humans was confirmed, through detection of the MC-specific protease, chymase, levels of which were significantly correlated with disease severity. These results support the association of MC activation with severe COVID-19, suggesting potential strategies for intervention. äSignatures of mast cell activation are associated with severe COVID-19(epmc).pdf DeepDyve Pubget Overpricing