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10.1038/s41598-021-91585-6 http://scihub22266oqcxt.onion/10.1038/s41598-021-91585-6 34099808!8184806!34099808     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 11998 Nephropedia Template TP {{tp|p=34099808|t=2021. SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |pdf=|usr=}}{{34099808}} gab.com Text SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34099808 #FOAvip Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, contributing towards studies of selective structure-based drug discovery and vaccine development. Twit Text FOAVip SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34099808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34099808 #FOAvip English Wikipedia <ref>{{Cite pmid|34099808}}</ref> SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions #MMPMID34099808 Timmers LFSM; Peixoto JV; Ducati RG; Bachega JFR; de Mattos Pereira L; Caceres RA; Majolo F; da Silva GL; Anton DB; Dellagostin OA; Henriques JAP; Xavier LL; Goettert MI; Laufer S Sci Rep 2021[Jun]; 11 (1): 11998 PMID34099808show ga Due to the high rate of transmissibility, Brazil became the new COVID-19 outbreak epicenter and, since then, is being monitored to understand how SARS-CoV-2 mutates and spreads. We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells. Structural analysis brought to light the positions of these mutations on protein structures, contributing towards studies of selective structure-based drug discovery and vaccine development. |Brazil[MESH] |COVID-19/*genetics[MESH] |Genome, Viral[MESH] |Genomics[MESH] |Humans[MESH] |Mutation/*genetics[MESH] |SARS-CoV-2/*genetics/pathogenicity[MESH] |Severity of Illness Index[MESH]SARS-CoV-2 mutations in Brazil: from genomics to putative clinical con(epmc).pdf DeepDyve Pubget Overpricing