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10.1038/s41467-021-23494-1 http://scihub22266oqcxt.onion/10.1038/s41467-021-23494-1 34099652!8184784!34099652     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34099652&cmd=llinks): Failed to open stream: HTTP request failed! 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SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care |pdf=|usr=}}{{34099652}} gab.com Text SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34099652 #FOAvip Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples (n = 474) from hospitalized COVID-19 patients (n = 123), non-COVID-19 ICU sepsis patients (n = 25) and healthy controls (n = 30). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in plasma or serum (RNAemia) of COVID-19 ICU patients when neutralizing antibody response was low. RNAemia is associated with higher 28-day ICU mortality (hazard ratio [HR], 1.84 [95% CI, 1.22-2.77] adjusted for age and sex). RNAemia is comparable in performance to the best protein predictors. Mannose binding lectin 2 and pentraxin-3 (PTX3), two activators of the complement pathway of the innate immune system, are positively associated with mortality. Machine learning identified 'Age, RNAemia' and 'Age, PTX3' as the best binary signatures associated with 28-day ICU mortality. In longitudinal comparisons, COVID-19 ICU patients have a distinct proteomic trajectory associated with mortality, with recovery of many liver-derived proteins indicating survival. Finally, proteins of the complement system and galectin-3-binding protein (LGALS3BP) are identified as interaction partners of SARS-CoV-2 spike glycoprotein. LGALS3BP overexpression inhibits spike-pseudoparticle uptake and spike-induced cell-cell fusion in vitro. Twit Text FOAVip SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34099652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34099652 #FOAvip English Wikipedia <ref>{{Cite pmid|34099652}}</ref> SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care #MMPMID34099652 Gutmann C; Takov K; Burnap SA; Singh B; Ali H; Theofilatos K; Reed E; Hasman M; Nabeebaccus A; Fish M; McPhail MJ; O'Gallagher K; Schmidt LE; Cassel C; Rienks M; Yin X; Auzinger G; Napoli S; Mujib SF; Trovato F; Sanderson B; Merrick B; Niazi U; Saqi M; Dimitrakopoulou K; Fernandez-Leiro R; Braun S; Kronstein-Wiedemann R; Doores KJ; Edgeworth JD; Shah AM; Bornstein SR; Tonn T; Hayday AC; Giacca M; Shankar-Hari M; Mayr M Nat Commun 2021[Jun]; 12 (1): 3406 PMID34099652show ga Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19). We obtained blood samples (n = 474) from hospitalized COVID-19 patients (n = 123), non-COVID-19 ICU sepsis patients (n = 25) and healthy controls (n = 30). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in plasma or serum (RNAemia) of COVID-19 ICU patients when neutralizing antibody response was low. RNAemia is associated with higher 28-day ICU mortality (hazard ratio [HR], 1.84 [95% CI, 1.22-2.77] adjusted for age and sex). RNAemia is comparable in performance to the best protein predictors. Mannose binding lectin 2 and pentraxin-3 (PTX3), two activators of the complement pathway of the innate immune system, are positively associated with mortality. Machine learning identified 'Age, RNAemia' and 'Age, PTX3' as the best binary signatures associated with 28-day ICU mortality. In longitudinal comparisons, COVID-19 ICU patients have a distinct proteomic trajectory associated with mortality, with recovery of many liver-derived proteins indicating survival. Finally, proteins of the complement system and galectin-3-binding protein (LGALS3BP) are identified as interaction partners of SARS-CoV-2 spike glycoprotein. LGALS3BP overexpression inhibits spike-pseudoparticle uptake and spike-induced cell-cell fusion in vitro. |Adult[MESH] |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antigens, Neoplasm/metabolism[MESH] |Biomarkers, Tumor/metabolism[MESH] |C-Reactive Protein/metabolism[MESH] |COVID-19/metabolism/*prevention & control/virology[MESH] |Critical Care/*statistics & numerical data[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Kaplan-Meier Estimate[MESH] |Male[MESH] |Middle Aged[MESH] |Proteomics/*methods[MESH] |RNA, Viral/blood/*genetics[MESH] |SARS-CoV-2/*genetics/metabolism/physiology[MESH] |Serum Amyloid P-Component/metabolism[MESH] |Spike Glycoprotein, Coronavirus/immunology/metabolism[MESH]SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication i(epmc).pdf DeepDyve Pubget Overpricing