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10.1186/s12879-021-06241-1

http://scihub22266oqcxt.onion/10.1186/s12879-021-06241-1
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34098889!8182762!34098889
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suck abstract from ncbi


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pmid34098889      BMC+Infect+Dis 2021 ; 21 (1): 536
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  • Pathogenesis-based preexposure prophylaxis associated with a low risk of SARS-CoV-2 infection in healthcare workers at a designated COVID-19 hospital: a pilot study #MMPMID34098889
  • Dubina MV; Gomonova VV; Taraskina AE; Vasilyeva NV; Sayganov SA
  • BMC Infect Dis 2021[Jun]; 21 (1): 536 PMID34098889show ga
  • BACKGROUND: At present, no agents are known to be effective at preventing COVID-19. Based on current knowledge of the pathogenesis of this disease, we suggest that SARS-CoV-2 infection might be attenuated by directly maintaining innate pulmonary redox, metabolic and dilation functions using well-tolerated medications that are known to serve these functions, specifically, a low-dose aerosolized combination of glutathione, inosine and potassium. METHODS: From June 1 to July 10, 2020, we conducted a pilot, prospective, open-label, single-arm, single-center study to evaluate the safety and efficacy of preexposure prophylaxis (PrEP) with aerosolized combination medication (ACM) on the incidence of SARS-CoV-2 positivity in 99 healthcare workers (HCWs) at a hospital designated for treating COVID-19 patients. We compared SARS-CoV-2 positivity in ACM users to retrospective data collected from 268 untreated HCWs at the same hospital. Eligible participants received an aerosolized combination of 21.3 mg/ml glutathione and 8.7 mg/ml inosine in 107 mM potassium solution for 14 days. The main outcome was the frequency of laboratory-confirmed SARS-CoV-2 cases, defined as individuals with positive genetic or immunological tests within 28 days of the study period. RESULTS: SARS-CoV-2 was detected in 2 ACM users (2, 95% CI: 0.3 to 7.1%), which was significantly less than the incidence in nonusers, at 24 (9, 95% CI: 5.8 to 13.0%; P = 0.02). During the PrEP period, solicited adverse events occurred in five participants; all were mild and transient reactions. CONCLUSIONS: Our findings might be used either to prevent SARS-CoV-2 infection or to support ongoing and new research into more effective treatments for COVID-19. TRIAL REGISTRATION: ISRCTN, ISRCTN34160010 . Registered 14 September 2020 - Retrospectively registered.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Health Personnel[MESH]
  • |*Pre-Exposure Prophylaxis[MESH]
  • |Adult[MESH]
  • |Aerosols/pharmacology[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Female[MESH]
  • |Hospitals[MESH]
  • |Humans[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pilot Projects[MESH]
  • |Prospective Studies[MESH]
  • |Retrospective Studies[MESH]


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