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10.1016/j.mehy.2021.110612 http://scihub22266oqcxt.onion/10.1016/j.mehy.2021.110612 34098463!8133800!34098463     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2021 ; 152 (ä): 110612 Nephropedia Template TP {{tp|p=34098463|t=2021. Decorin as a possible strategy for the amelioration of COVID-19 |pdf=|usr=}}{{34098463}} gab.com Text Decorin as a possible strategy for the amelioration of COVID-19 JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=34098463 #FOAvip Coronavirus pandemic has emerged as an extraordinary healthcare crisis in modern times. The SARS-CoV-2 novel coronavirus has high transmission rate, is more aggressive and virulent in comparison to previously known coronaviruses. It primarily attacks the respiratory system by inducing cytokine storm that causes systemic inflammation and pulmonary fibrosis. Decorin is a pluripotent molecule belonging to a leucine rich proteoglycan group that exerts critical role in extracellular matrix (ECM) assembly and regulates cell growth, adhesion, proliferation, inflammation, and fibrogenesis. Interestingly, decorin has potent anti-inflammatory, cytokine inhibitory, and anti-fibrillogenesis effects which make it a potential drug candidate against the COVID-19 related complications especially in the context of lung fibrosis. Herein, we postulate that owing to its distinctive pharmacological actions and immunomodulatory effect, decorin can be a promising preclinical therapeutic agent for the therapy of COVID-19. Twit Text FOAVip Decorin as a possible strategy for the amelioration of COVID-19 ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=34098463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34098463 #FOAvip English Wikipedia <ref>{{Cite pmid|34098463}}</ref> Decorin as a possible strategy for the amelioration of COVID-19 #MMPMID34098463 Allawadhi P; Singh V; Khurana I; Rawat PS; Renushe AP; Khurana A; Navik U; Allwadhi S; Kumar Karlapudi S; Banothu AK; Bharani KK Med Hypotheses 2021[Jul]; 152 (ä): 110612 PMID34098463show ga Coronavirus pandemic has emerged as an extraordinary healthcare crisis in modern times. The SARS-CoV-2 novel coronavirus has high transmission rate, is more aggressive and virulent in comparison to previously known coronaviruses. It primarily attacks the respiratory system by inducing cytokine storm that causes systemic inflammation and pulmonary fibrosis. Decorin is a pluripotent molecule belonging to a leucine rich proteoglycan group that exerts critical role in extracellular matrix (ECM) assembly and regulates cell growth, adhesion, proliferation, inflammation, and fibrogenesis. Interestingly, decorin has potent anti-inflammatory, cytokine inhibitory, and anti-fibrillogenesis effects which make it a potential drug candidate against the COVID-19 related complications especially in the context of lung fibrosis. Herein, we postulate that owing to its distinctive pharmacological actions and immunomodulatory effect, decorin can be a promising preclinical therapeutic agent for the therapy of COVID-19. |*COVID-19[MESH] |Cytokines[MESH] |Decorin[MESH] |Humans[MESH] |Pandemics[MESH]Decorin as a possible strategy for the amelioration of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing