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10.1016/j.biochi.2021.05.017 http://scihub22266oqcxt.onion/10.1016/j.biochi.2021.05.017 34097986!8449419!34097986     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochimie 2021 ; 189 (ä): 40-50 Nephropedia Template TP {{tp|p=34097986|t=2021. What do secreted phospholipases A(2) have to offer in combat against different viruses up to SARS-CoV-2?|pdf=|usr=}}{{34097986}} gab.com Text What do secreted phospholipases A(2) have to offer in combat against different viruses up to SARS-CoV-2 JO: Biochimie http://www.kidney.de/pget.php?&tw=1&pmid=34097986 #FOAvip Secreted phospholipases A(2) (sPLA(2)s) form a widespread group of structurally-related enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to produce free fatty acids and lysophospholipids. In humans, nine catalytically active and two inactive sPLA(2) proteins have been identified. These enzymes play diverse biological roles, including host defence against bacteria, parasites and viruses. Several of these endogenous sPLA(2)s may play a defensive role in viral infections, as they display in vitro antiviral activity by both direct and indirect mechanisms. However, endogenous sPLA(2)s may also exert an offensive and negative role, dampening the antiviral response or promoting inflammation in animal models of viral infection. Similarly, several exogenous sPLA(2)s, most of them from snake venoms and other animal venoms, possess in vitro antiviral activities. Thus, both endogenous and exogenous sPLA(2)s may be exploited for the development of new antiviral substances or as therapeutic targets for antagonistic drugs that may promote a more robust antiviral response. In this review, the antiviral versus proviral role of both endogenous and exogenous sPLA(2)s against various viruses including coronaviruses is presented. Based on the highlighted developments in this area of research, possible directions of future investigation are envisaged. One of them is also a possibility of exploiting sPLA(2)s as biological markers of the severity of the Covid-19 pandemic caused by SARS-CoV-2 infection. Twit Text FOAVip What do secreted phospholipases A(2) have to offer in combat against different viruses up to SARS-CoV-2 ????Biochimie http://www.kidney.de/pget.php?&tw=1&pmid=34097986 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34097986 #FOAvip English Wikipedia <ref>{{Cite pmid|34097986}}</ref> What do secreted phospholipases A(2) have to offer in combat against different viruses up to SARS-CoV-2? #MMPMID34097986 Pungercar J; Bihl F; Lambeau G; Krizaj I Biochimie 2021[Oct]; 189 (ä): 40-50 PMID34097986show ga Secreted phospholipases A(2) (sPLA(2)s) form a widespread group of structurally-related enzymes that catalyse the hydrolysis of the sn-2 ester bond of glycerophospholipids to produce free fatty acids and lysophospholipids. In humans, nine catalytically active and two inactive sPLA(2) proteins have been identified. These enzymes play diverse biological roles, including host defence against bacteria, parasites and viruses. Several of these endogenous sPLA(2)s may play a defensive role in viral infections, as they display in vitro antiviral activity by both direct and indirect mechanisms. However, endogenous sPLA(2)s may also exert an offensive and negative role, dampening the antiviral response or promoting inflammation in animal models of viral infection. Similarly, several exogenous sPLA(2)s, most of them from snake venoms and other animal venoms, possess in vitro antiviral activities. Thus, both endogenous and exogenous sPLA(2)s may be exploited for the development of new antiviral substances or as therapeutic targets for antagonistic drugs that may promote a more robust antiviral response. In this review, the antiviral versus proviral role of both endogenous and exogenous sPLA(2)s against various viruses including coronaviruses is presented. Based on the highlighted developments in this area of research, possible directions of future investigation are envisaged. One of them is also a possibility of exploiting sPLA(2)s as biological markers of the severity of the Covid-19 pandemic caused by SARS-CoV-2 infection. |*Pandemics[MESH] |Animals[MESH] |Antiviral Agents/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*enzymology/epidemiology/pathology[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Phospholipases A2, Secretory/*metabolism[MESH]What do secreted phospholipases A(2) have to offer in combat against d(epmc).pdf DeepDyve Pubget Overpricing