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10.1371/journal.ppat.1009662 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1009662 34097709!8211255!34097709     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2021 ; 17 (6): e1009662 Nephropedia Template TP {{tp|p=34097709|t=2021. Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways |pdf=|usr=}}{{34097709}} gab.com Text Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34097709 #FOAvip Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old World arenaviruses, Zika virus, vesicular stomatitis virus and pseudoviruses bearing the Machupo virus, Ebola virus and SARS-CoV-2 glycoproteins, but not HSV-1, MLV or mNoV. Moreover, mice with targeted mutation of the Sirpa gene that renders it non-functional were more susceptible to infection with the New World arenaviruses Junin virus vaccine strain Candid 1 and Tacaribe virus, but not MLV or mNoV. All SIRPA-inhibited viruses have in common the requirement for trafficking to a low pH endosomal compartment. This was clearly demonstrated with SARS-CoV-2 pseudovirus, which was only inhibited by SIRPA in cells in which it required trafficking to the endosome. Similar to its role in phagocytosis inhibition, SIRPA decreased virus internalization but not binding to cell surface receptors. We also found that increasing SIRPA levels via treatment with IL-4 led to even greater anti-viral activity. These data suggest that enhancing SIRPA's activity could be a target for anti-viral therapies. Twit Text FOAVip Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=34097709 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34097709 #FOAvip English Wikipedia <ref>{{Cite pmid|34097709}}</ref> Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways #MMPMID34097709 Sarute N; Cheng H; Yan Z; Salas-Briceno K; Richner J; Rong L; Ross SR PLoS Pathog 2021[Jun]; 17 (6): e1009662 PMID34097709show ga Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World and Old World arenaviruses, Zika virus, vesicular stomatitis virus and pseudoviruses bearing the Machupo virus, Ebola virus and SARS-CoV-2 glycoproteins, but not HSV-1, MLV or mNoV. Moreover, mice with targeted mutation of the Sirpa gene that renders it non-functional were more susceptible to infection with the New World arenaviruses Junin virus vaccine strain Candid 1 and Tacaribe virus, but not MLV or mNoV. All SIRPA-inhibited viruses have in common the requirement for trafficking to a low pH endosomal compartment. This was clearly demonstrated with SARS-CoV-2 pseudovirus, which was only inhibited by SIRPA in cells in which it required trafficking to the endosome. Similar to its role in phagocytosis inhibition, SIRPA decreased virus internalization but not binding to cell surface receptors. We also found that increasing SIRPA levels via treatment with IL-4 led to even greater anti-viral activity. These data suggest that enhancing SIRPA's activity could be a target for anti-viral therapies. |*Endocytosis[MESH] |*Virus Internalization[MESH] |Animals[MESH] |Antiviral Agents/pharmacology[MESH] |Cell Line[MESH] |Cell Membrane/virology[MESH] |Chlorocebus aethiops[MESH] |Drug Delivery Systems[MESH] |Integrins/immunology[MESH] |Interleukin-4/pharmacology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Protein Domains[MESH] |RNA Viruses/*immunology[MESH] |Receptors, Immunologic/genetics/*physiology[MESH]Signal-regulatory protein alpha is an anti-viral entry factor targetin(epmc).pdf DeepDyve Pubget Overpricing