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10.22074/cellj.2021.7977

http://scihub22266oqcxt.onion/10.22074/cellj.2021.7977
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34096226!8181318!34096226
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suck abstract from ncbi

pmid34096226      Cell+J 2021 ; 23 (2): 247-250
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  • Is There any Alternative Receptor for SARS-CoV-2? #MMPMID34096226
  • Shahriari Felordi M; Memarnejadian A; Najimi M; Vosough M
  • Cell J 2021[Jul]; 23 (2): 247-250 PMID34096226show ga
  • Angiotensin-converting enzyme II (ACE2) in association with type II transmembrane serine protease (TMPRSS2) is considered the main receptor of SARS-CoV-2. However, considering the clinical complications of COVID-19 in different organs, there is no strong association between the abundance of ACE2/TMPRSS2 co-expression and clinical features of the disease and the severity of complications. Since SARS-CoV-2 affects certain organs that lack or have low expression of ACE2/TMPRSS2, it may be possible that the virus employs other receptors for colonization and entry. Based on recent studies, glucose-regulated protein 78 (GRP78) can be a potential alternative receptor for SARS-CoV-2 entry. In this letter, supporting evidence proposed GRP78 as an alternative receptor in SARS-CoV-2 infection.
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