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10.1016/j.isci.2021.102681 http://scihub22266oqcxt.onion/10.1016/j.isci.2021.102681 34095780!8168301!34095780     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2021 ; 24 (6): 102681 Nephropedia Template TP {{tp|p=34095780|t=2021. Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain |pdf=|usr=}}{{34095780}} gab.com Text Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=34095780 #FOAvip Nucleocapsid (N) encoded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays key roles in the replication cycle and is a critical serological marker. Here, we characterize essential biochemical properties of N and describe the utility of these insights in serological studies. We define N domains important for oligomerization and RNA binding and show that N oligomerization provides a high-affinity RNA-binding platform. We also map the RNA-binding interface, showing protection in the N-terminal domain and linker region. In addition, phosphorylation causes reduction of RNA binding and redistribution of N from liquid droplets to loose coils, showing how N-RNA accessibility and assembly may be regulated by phosphorylation. Finally, we find that the C-terminal domain of N is the most immunogenic, based on antibody binding to patient samples. Together, we provide a biochemical description of SARS-CoV-2 N and highlight the value of using N domains as highly specific and sensitive diagnostic markers. Twit Text FOAVip Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=34095780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34095780 #FOAvip English Wikipedia <ref>{{Cite pmid|34095780}}</ref> Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain #MMPMID34095780 Wu C; Qavi AJ; Hachim A; Kavian N; Cole AR; Moyle AB; Wagner ND; Sweeney-Gibbons J; Rohrs HW; Gross ML; Peiris JSM; Basler CF; Farnsworth CW; Valkenburg SA; Amarasinghe GK; Leung DW iScience 2021[Jun]; 24 (6): 102681 PMID34095780show ga Nucleocapsid (N) encoded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays key roles in the replication cycle and is a critical serological marker. Here, we characterize essential biochemical properties of N and describe the utility of these insights in serological studies. We define N domains important for oligomerization and RNA binding and show that N oligomerization provides a high-affinity RNA-binding platform. We also map the RNA-binding interface, showing protection in the N-terminal domain and linker region. In addition, phosphorylation causes reduction of RNA binding and redistribution of N from liquid droplets to loose coils, showing how N-RNA accessibility and assembly may be regulated by phosphorylation. Finally, we find that the C-terminal domain of N is the most immunogenic, based on antibody binding to patient samples. Together, we provide a biochemical description of SARS-CoV-2 N and highlight the value of using N domains as highly specific and sensitive diagnostic markers. äCharacterization of SARS-CoV-2 nucleocapsid protein reveals multiple f(epmc).pdf DeepDyve Pubget Overpricing