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10.1016/j.cocis.2021.101468 http://scihub22266oqcxt.onion/10.1016/j.cocis.2021.101468 34093062!8164502!34093062     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Colloid+Interface+Sci 2021 ; 55 (ä): 101468 Nephropedia Template TP {{tp|p=34093062|t=2021. Opportunities for innovation: Building on the success of lipid nanoparticle vaccines |pdf=|usr=}}{{34093062}} gab.com Text Opportunities for innovation: Building on the success of lipid nanoparticle vaccines JO: Curr Opin Colloid Interface Sci http://www.kidney.de/pget.php?&tw=1&pmid=34093062 #FOAvip Lipid nanoparticle (LNP) formulations of messenger RNA (mRNA) have demonstrated high efficacy as vaccines against SARS-CoV-2. The success of these nanoformulations underscores the potential of LNPs as a delivery system for next-generation biological therapies. In this article, we highlight the key considerations necessary for engineering LNPs as a vaccine delivery system and explore areas for further optimisation. There remain opportunities to improve the protection of mRNA, optimise cytosolic delivery, target specific cells, minimise adverse side-effects and control the release of RNA from the particle. The modular nature of LNP formulations and the flexibility of mRNA as a payload provide many pathways to implement these strategies. Innovation in LNP vaccines is likely to accelerate with increased enthusiasm following recent successes; however, any advances will have implications for a broad range of therapeutic applications beyond vaccination such as gene therapy. Twit Text FOAVip Opportunities for innovation: Building on the success of lipid nanoparticle vaccines ????Curr Opin Colloid Interface Sci http://www.kidney.de/pget.php?&tw=1&pmid=34093062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34093062 #FOAvip English Wikipedia <ref>{{Cite pmid|34093062}}</ref> Opportunities for innovation: Building on the success of lipid nanoparticle vaccines #MMPMID34093062 Huang J; Yuen D; Mintern JD; Johnston APR Curr Opin Colloid Interface Sci 2021[Oct]; 55 (ä): 101468 PMID34093062show ga Lipid nanoparticle (LNP) formulations of messenger RNA (mRNA) have demonstrated high efficacy as vaccines against SARS-CoV-2. The success of these nanoformulations underscores the potential of LNPs as a delivery system for next-generation biological therapies. In this article, we highlight the key considerations necessary for engineering LNPs as a vaccine delivery system and explore areas for further optimisation. There remain opportunities to improve the protection of mRNA, optimise cytosolic delivery, target specific cells, minimise adverse side-effects and control the release of RNA from the particle. The modular nature of LNP formulations and the flexibility of mRNA as a payload provide many pathways to implement these strategies. Innovation in LNP vaccines is likely to accelerate with increased enthusiasm following recent successes; however, any advances will have implications for a broad range of therapeutic applications beyond vaccination such as gene therapy. äOpportunities for innovation: Building on the success of lipid nanopar(epmc).pdf DeepDyve Pubget Overpricing