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10.1111/ajt.16708 http://scihub22266oqcxt.onion/10.1111/ajt.16708 34092033!8222887!34092033     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2021 ; 21 (8): 2785-2794 Nephropedia Template TP {{tp|p=34092033|t=2021. T cell-mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19 |pdf=|usr=}}{{34092033}} gab.com Text T cell-mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19 JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=34092033 #FOAvip Whether immunosuppression impairs severe acute respiratory syndrome coronavirus 2-specific T cell-mediated immunity (SARS-CoV-2-CMI) after liver transplantation (LT) remains unknown. We included 31 LT recipients in whom SARS-CoV-2-CMI was assessed by intracellular cytokine staining (ICS) and interferon (IFN)-gamma FluoroSpot assay after a median of 103 days from COVID-19 diagnosis. Serum SARS-CoV-2 IgG antibodies were measured by ELISA. A control group of nontransplant immunocompetent patients were matched (1:1 ratio) by age and time from diagnosis. Post-transplant SARS-CoV-2-CMI was detected by ICS in 90.3% (28/31) of recipients, with higher proportions for IFN-gamma-producing CD4(+) than CD8(+) responses (93.5% versus 83.9%). Positive spike-specific and nucleoprotein-specific responses were found by FluoroSpot in 86.7% (26/30) of recipients each, whereas membrane protein-specific response was present in 83.3% (25/30). An inverse correlation was observed between the number of spike-specific IFN-gamma-producing SFUs and time from diagnosis (Spearman's rho: -0.418; p value = .024). Two recipients (6.5%) failed to mount either T cell-mediated or IgG responses. There were no significant differences between LT recipients and nontransplant patients in the magnitude of responses by FluoroSpot to any of the antigens. Most LT recipients mount detectable-but declining over time-SARS-CoV-2-CMI after a median of 3 months from COVID-19, with no meaningful differences with immunocompetent patients. Twit Text FOAVip T cell-mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19 ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=34092033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34092033 #FOAvip English Wikipedia <ref>{{Cite pmid|34092033}}</ref> T cell-mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19 #MMPMID34092033 Fernandez-Ruiz M; Olea B; Almendro-Vazquez P; Gimenez E; Marcacuzco A; San Juan R; Justo I; Calvo-Pulido J; Garcia-Sesma A; Manrique A; Caso O; Cambra F; Talayero P; Lopez-Medrano F; Remigia MJ; Ruiz-Merlo T; Parra P; Paz-Artal E; Jimenez C; Loinaz C; Navarro D; Laguna-Goya R; Aguado JM Am J Transplant 2021[Aug]; 21 (8): 2785-2794 PMID34092033show ga Whether immunosuppression impairs severe acute respiratory syndrome coronavirus 2-specific T cell-mediated immunity (SARS-CoV-2-CMI) after liver transplantation (LT) remains unknown. We included 31 LT recipients in whom SARS-CoV-2-CMI was assessed by intracellular cytokine staining (ICS) and interferon (IFN)-gamma FluoroSpot assay after a median of 103 days from COVID-19 diagnosis. Serum SARS-CoV-2 IgG antibodies were measured by ELISA. A control group of nontransplant immunocompetent patients were matched (1:1 ratio) by age and time from diagnosis. Post-transplant SARS-CoV-2-CMI was detected by ICS in 90.3% (28/31) of recipients, with higher proportions for IFN-gamma-producing CD4(+) than CD8(+) responses (93.5% versus 83.9%). Positive spike-specific and nucleoprotein-specific responses were found by FluoroSpot in 86.7% (26/30) of recipients each, whereas membrane protein-specific response was present in 83.3% (25/30). An inverse correlation was observed between the number of spike-specific IFN-gamma-producing SFUs and time from diagnosis (Spearman's rho: -0.418; p value = .024). Two recipients (6.5%) failed to mount either T cell-mediated or IgG responses. There were no significant differences between LT recipients and nontransplant patients in the magnitude of responses by FluoroSpot to any of the antigens. Most LT recipients mount detectable-but declining over time-SARS-CoV-2-CMI after a median of 3 months from COVID-19, with no meaningful differences with immunocompetent patients. |*COVID-19[MESH] |*Liver Transplantation/adverse effects[MESH] |Antibodies, Viral[MESH] |COVID-19 Testing[MESH] |Humans[MESH] |SARS-CoV-2[MESH] |T-Lymphocytes[MESH]T cell-mediated response to SARS-CoV-2 in liver transplant recipients (epmc).pdf DeepDyve Pubget Overpricing