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10.1016/j.intimp.2021.107828 http://scihub22266oqcxt.onion/10.1016/j.intimp.2021.107828 34091116!8162824!34091116     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2021 ; 97 (ä): 107828 Nephropedia Template TP {{tp|p=34091116|t=2021. Different T cell related immunological profiles in COVID-19 patients compared to healthy controls |pdf=|usr=}}{{34091116}} gab.com Text Different T cell related immunological profiles in COVID-19 patients compared to healthy controls JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34091116 #FOAvip In various pathological conditions, cellular immunity plays an important role in immune responses. Amongimmunecells, T lymphocytes pdomotecellular and humoralresponses as well as innate immunity. Therefore, careful investigation of these cells has a significant impact on accurate knowledge in COVID-19diseasepathogenesis. In current research, the frequency and function of various T lymphocytes involved in immune responses examined in SARS-CoV-2 patients with various disease severity compared to normal subjects. In order to make an accurate comparison among patients with various disease severity, this study was performed on asymptomatic recovered cases (n = 20), ICU hospitalized patients (n = 30), non-ICU hospitalized patients (n = 30), and normal subjects (n = 20). To precisely evaluate T cells activity following purification, their cytokine secretion activity was examined. Similarly, immediately after purification of Treg cells, their inhibitory activity on T cells was investigated. The results showed that COVID-19 patients with severe disease (ICU hospitalized patients) not only had a remarkable increase in Th1 and Th17 but also a considerable decrease in Th2 and Treg cells. More importantly, as the IL-17 and IFN-gamma secretion was sharply increased in severe disease, the secretion of IL-10 and IL-4 was decreased. Furthermore, the inhibitory activity of Treg cells was reduced in severe disease patients in comparison to other groups. In severe COVID-19 disease, current findings indicate when the inflammatory arm of cellular immunity is significantly increased, a considerable reduction in anti-inflammatory and regulatory arm occurred. Twit Text FOAVip Different T cell related immunological profiles in COVID-19 patients compared to healthy controls ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34091116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34091116 #FOAvip English Wikipedia <ref>{{Cite pmid|34091116}}</ref> Different T cell related immunological profiles in COVID-19 patients compared to healthy controls #MMPMID34091116 Mahmoud Salehi Khesht A; Karpisheh V; Qubais Saeed B; Olegovna Zekiy A; Yapanto LM; Nabi Afjadi M; Aksoun M; Nasr Esfahani M; Aghakhani F; Movahed M; Joshi N; Abbaszadeh-Goudarzi K; Hallaj S; Ahmadi M; Dolati S; Mahmoodpoor A; Hashemi V; Jadidi-Niaragh F Int Immunopharmacol 2021[Aug]; 97 (ä): 107828 PMID34091116show ga In various pathological conditions, cellular immunity plays an important role in immune responses. Amongimmunecells, T lymphocytes pdomotecellular and humoralresponses as well as innate immunity. Therefore, careful investigation of these cells has a significant impact on accurate knowledge in COVID-19diseasepathogenesis. In current research, the frequency and function of various T lymphocytes involved in immune responses examined in SARS-CoV-2 patients with various disease severity compared to normal subjects. In order to make an accurate comparison among patients with various disease severity, this study was performed on asymptomatic recovered cases (n = 20), ICU hospitalized patients (n = 30), non-ICU hospitalized patients (n = 30), and normal subjects (n = 20). To precisely evaluate T cells activity following purification, their cytokine secretion activity was examined. Similarly, immediately after purification of Treg cells, their inhibitory activity on T cells was investigated. The results showed that COVID-19 patients with severe disease (ICU hospitalized patients) not only had a remarkable increase in Th1 and Th17 but also a considerable decrease in Th2 and Treg cells. More importantly, as the IL-17 and IFN-gamma secretion was sharply increased in severe disease, the secretion of IL-10 and IL-4 was decreased. Furthermore, the inhibitory activity of Treg cells was reduced in severe disease patients in comparison to other groups. In severe COVID-19 disease, current findings indicate when the inflammatory arm of cellular immunity is significantly increased, a considerable reduction in anti-inflammatory and regulatory arm occurred. |Adult[MESH] |Aged[MESH] |COVID-19/*blood/*immunology[MESH] |Cytokines/immunology/metabolism[MESH] |Female[MESH] |Healthy Volunteers[MESH] |Humans[MESH] |Immunity, Cellular[MESH] |Inflammation/metabolism[MESH] |Interferon-gamma/metabolism[MESH] |Interleukin-10/metabolism[MESH] |Interleukin-17/metabolism[MESH] |Interleukin-4/metabolism[MESH] |Leukocytes/immunology/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Severity of Illness Index[MESH] |T-Lymphocyte Subsets/*immunology/metabolism/*virology[MESH] |T-Lymphocytes, Regulatory/immunology/metabolism[MESH] |Th1 Cells/immunology/metabolism[MESH] |Th17 Cells/immunology/metabolism[MESH] |Th2 Cells/immunology/metabolism[MESH]Different T cell related immunological profiles in COVID-19 patients c(epmc).pdf DeepDyve Pubget Overpricing