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10.1016/j.ijid.2021.05.080

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.05.080
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suck abstract from ncbi


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pmid34091005      Int+J+Infect+Dis 2021 ; 108 (ä): 483-486
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  • Colloidal gold immunochromatographic assay (GICA) is an effective screening method for identifying detectable anti-SARS-CoV-2 neutralizing antibodies #MMPMID34091005
  • Li X; Yin Y; Pang L; Xu S; Lu F; Xu D; Shen T
  • Int J Infect Dis 2021[Jul]; 108 (ä): 483-486 PMID34091005show ga
  • INTRODUCTION: A large number of COVID-19 patients are in recovery, and millions of people are vaccinated for COVID-19 globally. This calls for a rapid screening strategy of SARS-CoV-2 protective antibodies, generated in rehabilitated and vaccinated populations. METHODS: Serum samples collected over a follow-up period of six months from 306 COVID-19 cases discharged from Wuhan Tongji Hospital were analyzed. Anti-S Abs were detected by colloidal gold immunochromatographic assay (GICA), and neutralizing antibodies (nAbs) were detected by chemiluminescent microparticle immunoassay (CMIA). RESULTS: Most COVID-19 survivors tested positive for anti-S Abs (83.7%) and nAbs (98.0%) 6 months after being discharged from the hospital, and the levels of anti-S Abs in the blood were highly positively correlated with nAbs (r = 0.652, P < 0.0001). The positivity rate of nAbs for patients with anti-S Abs positive was 100%. CONCLUSIONS: There is a good agreement between anti-S Abs detected by GICA and nAbs detected by CMIA. It indicates that anti-S Abs detected by GICA may be used as a cheaper screening strategy for detectable SARS-CoV-2 nAbs in COVID-19 convalescent individuals.
  • |*Antibodies, Neutralizing[MESH]
  • |*COVID-19[MESH]
  • |Antibodies, Viral[MESH]
  • |Gold Colloid[MESH]
  • |Humans[MESH]
  • |Immunoassay[MESH]


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