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10.1002/eji.202149234 http://scihub22266oqcxt.onion/10.1002/eji.202149234 34089541!8237060!34089541     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2021 ; 51 (9): 2296-2305 Nephropedia Template TP {{tp|p=34089541|t=2021. Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice |pdf=|usr=}}{{34089541}} gab.com Text Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34089541 #FOAvip The increasing numbers of infected cases of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses serious threats to public health and the global economy. Most SARS-CoV-2 neutralizing antibodies target the receptor binding domain (RBD) and some the N-terminal domain (NTD) of the spike protein, which is the major antigen of SARS-CoV-2. While the antibody response to RBD has been extensively characterized, the antigenicity and immunogenicity of the NTD protein are less well studied. Using 227 plasma samples from COVID-19 patients, we showed that SARS-CoV-2 NTD-specific antibodies could be induced during infection. As compared to the results of SARS-CoV-2 RBD, the serological response of SARS-CoV-2 NTD is less cross-reactive with SARS-CoV, a pandemic strain that was identified in 2003. Furthermore, neutralizing antibodies are rarely elicited in a mice model when NTD is used as an immunogen. We subsequently demonstrate that NTD has an altered antigenicity when expressed alone. Overall, our results suggest that while NTD offers a supplementary strategy for serology testing, it may not be suitable as an immunogen for vaccine development. Twit Text FOAVip Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34089541 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34089541 #FOAvip English Wikipedia <ref>{{Cite pmid|34089541}}</ref> Homologous and heterologous serological response to the N-terminal domain of SARS-CoV-2 in humans and mice #MMPMID34089541 Lv H; Tsang OT; So RTY; Wang Y; Yuan M; Liu H; Yip GK; Teo QW; Lin Y; Liang W; Wang J; Ng WW; Wilson IA; Peiris JSM; Wu NC; Mok CKP Eur J Immunol 2021[Sep]; 51 (9): 2296-2305 PMID34089541show ga The increasing numbers of infected cases of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses serious threats to public health and the global economy. Most SARS-CoV-2 neutralizing antibodies target the receptor binding domain (RBD) and some the N-terminal domain (NTD) of the spike protein, which is the major antigen of SARS-CoV-2. While the antibody response to RBD has been extensively characterized, the antigenicity and immunogenicity of the NTD protein are less well studied. Using 227 plasma samples from COVID-19 patients, we showed that SARS-CoV-2 NTD-specific antibodies could be induced during infection. As compared to the results of SARS-CoV-2 RBD, the serological response of SARS-CoV-2 NTD is less cross-reactive with SARS-CoV, a pandemic strain that was identified in 2003. Furthermore, neutralizing antibodies are rarely elicited in a mice model when NTD is used as an immunogen. We subsequently demonstrate that NTD has an altered antigenicity when expressed alone. Overall, our results suggest that while NTD offers a supplementary strategy for serology testing, it may not be suitable as an immunogen for vaccine development. |Animals[MESH] |Antibodies, Neutralizing/immunology[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/*immunology[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Cross Reactions/immunology[MESH] |Female[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Pandemics/prevention & control[MESH] |Protein Binding/immunology[MESH] |Protein Domains/*immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Sf9 Cells[MESH]Homologous and heterologous serological response to the N-terminal dom(epmc).pdf DeepDyve Pubget Overpricing