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10.1007/s00018-021-03832-8 http://scihub22266oqcxt.onion/10.1007/s00018-021-03832-8 34089346!8257531!34089346     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2021 ; 78 (13): 5427-5445 Nephropedia Template TP {{tp|p=34089346|t=2021. ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs |pdf=|usr=}}{{34089346}} gab.com Text ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=34089346 #FOAvip Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg(2+)) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation factor-like GTPase 15 (ARL15), a small GTP-binding protein. ARL15 interacts with CNNMs at their carboxyl-terminal conserved cystathionine-beta-synthase (CBS) domains. In silico modeling of the interaction between CNNM2 and ARL15 supports that the small GTPase specifically binds the CBS1 and CNBH domains. Immunocytochemical experiments demonstrate that CNNM2 and ARL15 co-localize in the kidney, with both proteins showing subcellular localization in the endoplasmic reticulum, Golgi apparatus and the plasma membrane. Most importantly, we found that ARL15 is required for forming complex N-glycosylation of CNNMs. Overexpression of ARL15 promotes complex N-glycosylation of CNNM3. Mg(2+) uptake experiments with a stable isotope demonstrate that there is a significant increase of (25)Mg(2+) uptake upon knockdown of ARL15 in multiple kidney cancer cell lines. Altogether, our results establish ARL15 as a novel negative regulator of Mg(2+) transport by promoting the complex N-glycosylation of CNNMs. Twit Text FOAVip ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=34089346 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34089346 #FOAvip English Wikipedia <ref>{{Cite pmid|34089346}}</ref> ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs #MMPMID34089346 Zolotarov Y; Ma C; Gonzalez-Recio I; Hardy S; Franken GAC; Uetani N; Latta F; Kostantin E; Boulais J; Thibault MP; Cote JF; Diaz-Moreno I; Quintana AD; Hoenderop JGJ; Martinez-Cruz LA; Tremblay ML; de Baaij JHF Cell Mol Life Sci 2021[Jul]; 78 (13): 5427-5445 PMID34089346show ga Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg(2+)) homeostasis. Using various biochemical approaches, we have identified members of the CNNM family as direct interacting partners of ADP-ribosylation factor-like GTPase 15 (ARL15), a small GTP-binding protein. ARL15 interacts with CNNMs at their carboxyl-terminal conserved cystathionine-beta-synthase (CBS) domains. In silico modeling of the interaction between CNNM2 and ARL15 supports that the small GTPase specifically binds the CBS1 and CNBH domains. Immunocytochemical experiments demonstrate that CNNM2 and ARL15 co-localize in the kidney, with both proteins showing subcellular localization in the endoplasmic reticulum, Golgi apparatus and the plasma membrane. Most importantly, we found that ARL15 is required for forming complex N-glycosylation of CNNMs. Overexpression of ARL15 promotes complex N-glycosylation of CNNM3. Mg(2+) uptake experiments with a stable isotope demonstrate that there is a significant increase of (25)Mg(2+) uptake upon knockdown of ARL15 in multiple kidney cancer cell lines. Altogether, our results establish ARL15 as a novel negative regulator of Mg(2+) transport by promoting the complex N-glycosylation of CNNMs. |*Homeostasis[MESH] |ADP-Ribosylation Factors/genetics/*metabolism[MESH] |Biological Transport[MESH] |Cyclins/genetics/*metabolism[MESH] |Glycosylation[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Magnesium/*metabolism[MESH] |Models, Molecular[MESH]ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs(epmc).pdf DeepDyve Pubget Overpricing