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10.1038/s41598-021-91417-7 http://scihub22266oqcxt.onion/10.1038/s41598-021-91417-7 34088975!8178312!34088975     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 11886 Nephropedia Template TP {{tp|p=34088975|t=2021. Regulation of the acetylcholine/alpha7nAChR anti-inflammatory pathway in COVID-19 patients |pdf=|usr=}}{{34088975}} gab.com Text Regulation of the acetylcholine/alpha7nAChR anti-inflammatory pathway in COVID-19 patients JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34088975 #FOAvip The cholinergic system has been proposed as a potential regulator of COVID-19-induced hypercytokinemia. We investigated whole-blood expression of cholinergic system members and correlated it with COVID-19 severity. Patients with confirmed SARS-CoV-2 infection and healthy aged-matched controls were included in this non-interventional study. A whole blood sample was drawn between 9-11 days after symptoms onset, and peripheral leukocyte phenotyping, cytokines measurement, RNA expression and plasma viral load were determined. Additionally, whole-blood expression of native alpha-7 nicotinic subunit and its negative dominant duplicate (CHRFAM7A), choline acetyltransferase and acetylcholine esterase (AchE) were determined. Thirty-seven patients with COVID-19 (10 moderate, 11 severe and 16 with critical disease) and 14 controls were included. Expression of CHRFAM7A was significantly lower in critical COVID-19 patients compared to controls. COVID-19 patients not expressing CHRFAM7A had higher levels of CRP, more extended pulmonary lesions and displayed more pronounced lymphopenia. COVID-19 patients without CHRFAM7A expression also showed increased TNF pathway expression in whole blood. AchE was also expressed in 30 COVID-19 patients and in all controls. COVID-19-induced hypercytokinemia is associated with decreased expression of the pro-inflammatory dominant negative duplicate CHRFAM7A. Expression of this duplicate might be considered before targeting the cholinergic system in COVID-19 with nicotine. Twit Text FOAVip Regulation of the acetylcholine/alpha7nAChR anti-inflammatory pathway in COVID-19 patients ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=34088975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34088975 #FOAvip English Wikipedia <ref>{{Cite pmid|34088975}}</ref> Regulation of the acetylcholine/alpha7nAChR anti-inflammatory pathway in COVID-19 patients #MMPMID34088975 Courties A; Boussier J; Hadjadj J; Yatim N; Barnabei L; Pere H; Veyer D; Kerneis S; Carlier N; Pene F; Rieux-Laucat F; Charbit B; Bondet V; Duffy D; Berenbaum F; Terrier B; Sellam J Sci Rep 2021[Jun]; 11 (1): 11886 PMID34088975show ga The cholinergic system has been proposed as a potential regulator of COVID-19-induced hypercytokinemia. We investigated whole-blood expression of cholinergic system members and correlated it with COVID-19 severity. Patients with confirmed SARS-CoV-2 infection and healthy aged-matched controls were included in this non-interventional study. A whole blood sample was drawn between 9-11 days after symptoms onset, and peripheral leukocyte phenotyping, cytokines measurement, RNA expression and plasma viral load were determined. Additionally, whole-blood expression of native alpha-7 nicotinic subunit and its negative dominant duplicate (CHRFAM7A), choline acetyltransferase and acetylcholine esterase (AchE) were determined. Thirty-seven patients with COVID-19 (10 moderate, 11 severe and 16 with critical disease) and 14 controls were included. Expression of CHRFAM7A was significantly lower in critical COVID-19 patients compared to controls. COVID-19 patients not expressing CHRFAM7A had higher levels of CRP, more extended pulmonary lesions and displayed more pronounced lymphopenia. COVID-19 patients without CHRFAM7A expression also showed increased TNF pathway expression in whole blood. AchE was also expressed in 30 COVID-19 patients and in all controls. COVID-19-induced hypercytokinemia is associated with decreased expression of the pro-inflammatory dominant negative duplicate CHRFAM7A. Expression of this duplicate might be considered before targeting the cholinergic system in COVID-19 with nicotine. |Acetylcholine/*immunology[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/genetics/*immunology[MESH] |Down-Regulation[MESH] |Female[MESH] |Humans[MESH] |Inflammation/genetics/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology[MESH]Regulation of the acetylcholine/alpha7nAChR anti-inflammatory pathway (epmc).pdf DeepDyve Pubget Overpricing