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10.1016/j.transci.2021.103174 http://scihub22266oqcxt.onion/10.1016/j.transci.2021.103174 34088601!?!34088601 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34088601&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Transfus+Apher+Sci 2021 ; 60 (4): 103174 Nephropedia Template TP {{tp|p=34088601|t=2021. Therapeutic plasma exchange (TPE) as a plausible rescue therapy in severe vaccine-induced immune thrombotic thrombocytopenia |pdf=|usr=}}{{34088601}} gab.com Text Therapeutic plasma exchange (TPE) as a plausible rescue therapy in severe vaccine-induced immune thrombotic thrombocytopenia JO: Transfus Apher Sci http://www.kidney.de/pget.php?&tw=1&pmid=34088601 #FOAvip Vaccine-induced immune thrombotic thrombocytopenia (VITT) is associated with high titers of immunoglobulin G class antibodies directed against the cationic platelet chemokine platelet factor 4 (PF4). These antibodies activate platelets via FcgammaIIa receptors. VITT closely resembles heparin-induced thrombocytopenia. Inflammation and tissue trauma substantially increase the risk for forming pathogenic PF4 antibodies. We therefore propose the use of therapeutic plasma exchange as rescue therapy in VITT to deplete antibodies plus factors promoting inflammation such as excess cytokines in the circulation as well as extracellular vesicles derived from activated platelets. Twit Text FOAVip Therapeutic plasma exchange (TPE) as a plausible rescue therapy in severe vaccine-induced immune thrombotic thrombocytopenia ????Transfus Apher Sci http://www.kidney.de/pget.php?&tw=1&pmid=34088601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34088601 #FOAvip English Wikipedia <ref>{{Cite pmid|34088601}}</ref> Therapeutic plasma exchange (TPE) as a plausible rescue therapy in severe vaccine-induced immune thrombotic thrombocytopenia #MMPMID34088601 Rock G; Weber V; Stegmayr B Transfus Apher Sci 2021[Aug]; 60 (4): 103174 PMID34088601show ga Vaccine-induced immune thrombotic thrombocytopenia (VITT) is associated with high titers of immunoglobulin G class antibodies directed against the cationic platelet chemokine platelet factor 4 (PF4). These antibodies activate platelets via FcgammaIIa receptors. VITT closely resembles heparin-induced thrombocytopenia. Inflammation and tissue trauma substantially increase the risk for forming pathogenic PF4 antibodies. We therefore propose the use of therapeutic plasma exchange as rescue therapy in VITT to deplete antibodies plus factors promoting inflammation such as excess cytokines in the circulation as well as extracellular vesicles derived from activated platelets. |*Plasma Exchange/adverse effects/methods[MESH] |*Salvage Therapy[MESH] |Albumins[MESH] |Antibody Specificity[MESH] |Anticoagulants[MESH] |Autoantibodies/immunology[MESH] |COVID-19 Vaccines/*adverse effects/pharmacology[MESH] |ChAdOx1 nCoV-19[MESH] |Citrates[MESH] |Contraindications, Procedure[MESH] |Cytokines/blood[MESH] |Extracellular Vesicles[MESH] |Humans[MESH] |Immunoglobulin G/immunology[MESH] |Immunosuppression Therapy[MESH] |Inflammation[MESH] |Platelet Activation[MESH] |Platelet Factor 4/*immunology[MESH] |Platelet Transfusion/adverse effects[MESH] |Purpura, Thrombotic Thrombocytopenic/etiology/immunology/*therapy[MESH] |Registries[MESH] |Thrombocytopenia/etiology[MESH]Therapeutic plasma exchange (TPE) as a plausible rescue therapy in sev(epmc).pdf DeepDyve Pubget Overpricing