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10.1186/s12985-021-01588-y http://scihub22266oqcxt.onion/10.1186/s12985-021-01588-y 34088317!8177255!34088317     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34088317&cmd=llinks): Failed to open stream: HTTP request failed! 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Specific cytokines in the inflammatory cytokine storm of patients with COVID-19-associated acute respiratory distress syndrome and extrapulmonary multiple-organ dysfunction |pdf=|usr=}}{{34088317}} gab.com Text Specific cytokines in the inflammatory cytokine storm of patients with COVID-19-associated acute respiratory distress syndrome and extrapulmonary multiple-organ dysfunction JO: Virol J http://www.kidney.de/pget.php?&tw=1&pmid=34088317 #FOAvip BACKGROUND: To date, specific cytokines associated with development of acute respiratory distress syndrome (ARDS) and extrapulmonary multiple organ dysfunction (MOD) in COVID-19 patients have not been systematically described. We determined the levels of inflammatory cytokines in patients with COVID-19 and their relationships with ARDS and extrapulmonary MOD. METHODS: The clinical and laboratory data of 94 COVID-19 patients with and without ARDS were analyzed. The levels of inflammatory cytokines (interleukin 6 [IL-6], IL-8, IL-10, and tumor necrosis factor alpha [TNF-alpha]) were measured on days 1, 3, and 5 following admission. Seventeen healthy volunteers were recruited as controls. Correlations in the levels of inflammatory cytokines with clinical and laboratory variables were analyzed, furthermore, we also explored the relationships of different cytokines with ARDS and extrapulmonary MOD. RESULTS: The ARDS group had higher serum levels of all 4 inflammatory cytokines than the controls, and these levels steadily increased after admission. The ARDS group also had higher levels of IL-6, IL-8, and IL-10 than the non-ARDS group, and the levels of these cytokines correlated significantly with coagulation parameters and disseminated intravascular coagulation (DIC). The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI). All 4 inflammatory cytokines had negative correlations with PaO(2)/FiO(2). IL-6, IL-8, and TNF-alpha had positive correlations with the APACHE-II score. Relative to survivors, non-survivors had higher levels of IL-6 and IL-10 at admission, and increasing levels over time. CONCLUSIONS: The cytokine storm apparently contributed to the development of ARDS and extrapulmonary MOD in COVID-19 patients. The levels of IL-6, IL-8, and IL-10 correlated with DIC, and the levels of IL-6 and TNF-alpha were associated with AKI. Relative to survivors, patients who died within 28 days had increased levels of IL-6 and IL-10. Twit Text FOAVip Specific cytokines in the inflammatory cytokine storm of patients with COVID-19-associated acute respiratory distress syndrome and extrapulmonary multiple-organ dysfunction ????Virol J http://www.kidney.de/pget.php?&tw=1&pmid=34088317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34088317 #FOAvip English Wikipedia <ref>{{Cite pmid|34088317}}</ref> Specific cytokines in the inflammatory cytokine storm of patients with COVID-19-associated acute respiratory distress syndrome and extrapulmonary multiple-organ dysfunction #MMPMID34088317 Wang J; Yang X; Li Y; Huang JA; Jiang J; Su N Virol J 2021[Jun]; 18 (1): 117 PMID34088317show ga BACKGROUND: To date, specific cytokines associated with development of acute respiratory distress syndrome (ARDS) and extrapulmonary multiple organ dysfunction (MOD) in COVID-19 patients have not been systematically described. We determined the levels of inflammatory cytokines in patients with COVID-19 and their relationships with ARDS and extrapulmonary MOD. METHODS: The clinical and laboratory data of 94 COVID-19 patients with and without ARDS were analyzed. The levels of inflammatory cytokines (interleukin 6 [IL-6], IL-8, IL-10, and tumor necrosis factor alpha [TNF-alpha]) were measured on days 1, 3, and 5 following admission. Seventeen healthy volunteers were recruited as controls. Correlations in the levels of inflammatory cytokines with clinical and laboratory variables were analyzed, furthermore, we also explored the relationships of different cytokines with ARDS and extrapulmonary MOD. RESULTS: The ARDS group had higher serum levels of all 4 inflammatory cytokines than the controls, and these levels steadily increased after admission. The ARDS group also had higher levels of IL-6, IL-8, and IL-10 than the non-ARDS group, and the levels of these cytokines correlated significantly with coagulation parameters and disseminated intravascular coagulation (DIC). The levels of IL-6 and TNF-alpha correlated with the levels of creatinine and urea nitrogen, and were also higher in ARDS patients with acute kidney injury (AKI). All 4 inflammatory cytokines had negative correlations with PaO(2)/FiO(2). IL-6, IL-8, and TNF-alpha had positive correlations with the APACHE-II score. Relative to survivors, non-survivors had higher levels of IL-6 and IL-10 at admission, and increasing levels over time. CONCLUSIONS: The cytokine storm apparently contributed to the development of ARDS and extrapulmonary MOD in COVID-19 patients. The levels of IL-6, IL-8, and IL-10 correlated with DIC, and the levels of IL-6 and TNF-alpha were associated with AKI. Relative to survivors, patients who died within 28 days had increased levels of IL-6 and IL-10. |Acute Kidney Injury/diagnosis[MESH] |Aged[MESH] |Blood Urea Nitrogen[MESH] |COVID-19/*blood/pathology[MESH] |Creatinine/blood[MESH] |Cytokine Release Syndrome/*blood/diagnosis[MESH] |Cytokines/*blood[MESH] |Disseminated Intravascular Coagulation/blood/pathology[MESH] |Female[MESH] |Humans[MESH] |Interleukin-10/blood[MESH] |Interleukin-6/blood[MESH] |Interleukin-8/blood[MESH] |Male[MESH] |Respiratory Distress Syndrome/*blood/pathology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Specific cytokines in the inflammatory cytokine storm of patients with(epmc).pdf DeepDyve Pubget Overpricing