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10.1016/j.ijbiomac.2021.05.192 http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2021.05.192 34087309!8266766!34087309     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Biol+Macromol 2021 ; 183 (ä): 2055-2073 Nephropedia Template TP {{tp|p=34087309|t=2021. A review of the tortuous path of nonviral gene delivery and recent progress |pdf=|usr=}}{{34087309}} gab.com Text A review of the tortuous path of nonviral gene delivery and recent progress JO: Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=34087309 #FOAvip Gene therapy encompasses the transfer of exogenous genetic materials into the patient's target cells to treat or prevent diseases. Nevertheless, the transfer of genetic material into desired cells is challenging and often requires specialized tools or delivery systems. For the past 40 years, scientists are mainly pursuing various viruses as gene delivery vectors, and the overall progress has been slow and far from the expectation. As an alternative, nonviral vectors have gained substantial attention due to their several advantages, including superior safety profile, enhanced payload capacity, and stealth abilities. Since nonviral vectors encounter multiple extra- and intra-cellular barriers limiting the transfer of genetic payload into the target cell nucleus, we have discussed these barriers in detail for this review. A direct approach, utilizing physical methods like electroporation, sonoporation, gene gun, eliminate the requirement for a specific carrier for gene delivery. In contrast, chemical methods of gene transfer exploit natural or synthetic compounds as carriers to increase cellular targeting and gene therapy effectiveness. We have also emphasized the recent advancements aimed at enhancing the current nonviral approaches. Therefore, in this review, we have focused on discussing the current evolving state of nonviral gene delivery systems and their future perspectives. Twit Text FOAVip A review of the tortuous path of nonviral gene delivery and recent progress ????Int J Biol Macromol http://www.kidney.de/pget.php?&tw=1&pmid=34087309 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34087309 #FOAvip English Wikipedia <ref>{{Cite pmid|34087309}}</ref> A review of the tortuous path of nonviral gene delivery and recent progress #MMPMID34087309 Sharma D; Arora S; Singh J; Layek B Int J Biol Macromol 2021[Jul]; 183 (ä): 2055-2073 PMID34087309show ga Gene therapy encompasses the transfer of exogenous genetic materials into the patient's target cells to treat or prevent diseases. Nevertheless, the transfer of genetic material into desired cells is challenging and often requires specialized tools or delivery systems. For the past 40 years, scientists are mainly pursuing various viruses as gene delivery vectors, and the overall progress has been slow and far from the expectation. As an alternative, nonviral vectors have gained substantial attention due to their several advantages, including superior safety profile, enhanced payload capacity, and stealth abilities. Since nonviral vectors encounter multiple extra- and intra-cellular barriers limiting the transfer of genetic payload into the target cell nucleus, we have discussed these barriers in detail for this review. A direct approach, utilizing physical methods like electroporation, sonoporation, gene gun, eliminate the requirement for a specific carrier for gene delivery. In contrast, chemical methods of gene transfer exploit natural or synthetic compounds as carriers to increase cellular targeting and gene therapy effectiveness. We have also emphasized the recent advancements aimed at enhancing the current nonviral approaches. Therefore, in this review, we have focused on discussing the current evolving state of nonviral gene delivery systems and their future perspectives. |*Gene Transfer Techniques/adverse effects[MESH] |*Genetic Therapy/adverse effects[MESH] |*Lipids/chemistry[MESH] |*Polymers/chemistry[MESH] |Animals[MESH] |Humans[MESH]A review of the tortuous path of nonviral gene delivery and recent pro(epmc).pdf DeepDyve Pubget Overpricing