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10.1038/s42003-021-02231-w http://scihub22266oqcxt.onion/10.1038/s42003-021-02231-w 34083758!8175581!34083758     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 698 Nephropedia Template TP {{tp|p=34083758|t=2021. Single-nucleotide conservation state annotation of the SARS-CoV-2 genome |pdf=|usr=}}{{34083758}} gab.com Text Single-nucleotide conservation state annotation of the SARS-CoV-2 genome JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34083758 #FOAvip Given the global impact and severity of COVID-19, there is a pressing need for a better understanding of the SARS-CoV-2 genome and mutations. Multi-strain sequence alignments of coronaviruses (CoV) provide important information for interpreting the genome and its variation. We apply a comparative genomics method, ConsHMM, to the multi-strain alignments of CoV to annotate every base of the SARS-CoV-2 genome with conservation states based on sequence alignment patterns among CoV. The learned conservation states show distinct enrichment patterns for genes, protein domains, and other regions of interest. Certain states are strongly enriched or depleted of SARS-CoV-2 mutations, which can be used to predict potentially consequential mutations. We expect the conservation states to be a resource for interpreting the SARS-CoV-2 genome and mutations. Twit Text FOAVip Single-nucleotide conservation state annotation of the SARS-CoV-2 genome ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34083758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34083758 #FOAvip English Wikipedia <ref>{{Cite pmid|34083758}}</ref> Single-nucleotide conservation state annotation of the SARS-CoV-2 genome #MMPMID34083758 Kwon SB; Ernst J Commun Biol 2021[Jun]; 4 (1): 698 PMID34083758show ga Given the global impact and severity of COVID-19, there is a pressing need for a better understanding of the SARS-CoV-2 genome and mutations. Multi-strain sequence alignments of coronaviruses (CoV) provide important information for interpreting the genome and its variation. We apply a comparative genomics method, ConsHMM, to the multi-strain alignments of CoV to annotate every base of the SARS-CoV-2 genome with conservation states based on sequence alignment patterns among CoV. The learned conservation states show distinct enrichment patterns for genes, protein domains, and other regions of interest. Certain states are strongly enriched or depleted of SARS-CoV-2 mutations, which can be used to predict potentially consequential mutations. We expect the conservation states to be a resource for interpreting the SARS-CoV-2 genome and mutations. |*Genome, Viral[MESH] |Animals[MESH] |Base Sequence[MESH] |COVID-19/*virology[MESH] |Conserved Sequence[MESH] |Evolution, Molecular[MESH] |Genomics[MESH] |Humans[MESH] |Mutation[MESH] |Nucleotides/genetics[MESH] |SARS-CoV-2/*genetics[MESH]Single-nucleotide conservation state annotation of the SARS-CoV-2 geno(epmc).pdf DeepDyve Pubget Overpricing