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10.1073/pnas.2024815118 http://scihub22266oqcxt.onion/10.1073/pnas.2024815118 34083352!8237675!34083352     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2021 ; 118 (25): ä Nephropedia Template TP {{tp|p=34083352|t=2021. The total number and mass of SARS-CoV-2 virions |pdf=|usr=}}{{34083352}} gab.com Text The total number and mass of SARS-CoV-2 virions JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34083352 #FOAvip Quantitatively describing the time course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for understanding the current global pandemic and possible ways to combat it. Here we integrate the best current knowledge about the typical viral load of SARS-CoV-2 in bodily fluids and host tissues to estimate the total number and mass of SARS-CoV-2 virions in an infected person. We estimate that each infected person carries 10(9) to 10(11) virions during peak infection, with a total mass in the range of 1 mug to 100 mug, which curiously implies that all SARS-CoV-2 virions currently circulating within human hosts have a collective mass of only 0.1 kg to 10 kg. We combine our estimates with the available literature on host immune response and viral mutation rates to demonstrate how antibodies markedly outnumber the spike proteins, and the genetic diversity of virions in an infected host covers all possible single nucleotide substitutions. Twit Text FOAVip The total number and mass of SARS-CoV-2 virions ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34083352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34083352 #FOAvip English Wikipedia <ref>{{Cite pmid|34083352}}</ref> The total number and mass of SARS-CoV-2 virions #MMPMID34083352 Sender R; Bar-On YM; Gleizer S; Bernshtein B; Flamholz A; Phillips R; Milo R Proc Natl Acad Sci U S A 2021[Jun]; 118 (25): ä PMID34083352show ga Quantitatively describing the time course of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection within an infected individual is important for understanding the current global pandemic and possible ways to combat it. Here we integrate the best current knowledge about the typical viral load of SARS-CoV-2 in bodily fluids and host tissues to estimate the total number and mass of SARS-CoV-2 virions in an infected person. We estimate that each infected person carries 10(9) to 10(11) virions during peak infection, with a total mass in the range of 1 mug to 100 mug, which curiously implies that all SARS-CoV-2 virions currently circulating within human hosts have a collective mass of only 0.1 kg to 10 kg. We combine our estimates with the available literature on host immune response and viral mutation rates to demonstrate how antibodies markedly outnumber the spike proteins, and the genetic diversity of virions in an infected host covers all possible single nucleotide substitutions. |*Viral Load[MESH] |COVID-19/*virology[MESH] |Humans[MESH] |SARS-CoV-2/*physiology[MESH] |Serologic Tests[MESH]The total number and mass of SARS-CoV-2 virions (epmc).pdf DeepDyve Pubget Overpricing