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10.1111/cei.13623

http://scihub22266oqcxt.onion/10.1111/cei.13623
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34082475!8239842!34082475
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suck abstract from ncbi


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pmid34082475      Clin+Exp+Immunol 2021 ; 205 (2): 99-105
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  • Establishing the prevalence of common tissue-specific autoantibodies following severe acute respiratory syndrome coronavirus 2 infection #MMPMID34082475
  • Richter AG; Shields AM; Karim A; Birch D; Faustini SE; Steadman L; Ward K; Plant T; Reynolds G; Veenith T; Cunningham AF; Drayson MT; Wraith DC
  • Clin Exp Immunol 2021[Aug]; 205 (2): 99-105 PMID34082475show ga
  • Coronavirus 19 (COVID-19) has been associated with both transient and persistent systemic symptoms that do not appear to be a direct consequence of viral infection. The generation of autoantibodies has been proposed as a mechanism to explain these symptoms. To understand the prevalence of autoantibodies associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we investigated the frequency and specificity of clinically relevant autoantibodies in 84 individuals previously infected with SARS-CoV-2, suffering from COVID-19 of varying severity in both the acute and convalescent setting. These were compared with results from 32 individuals who were on the intensive therapy unit (ITU) for non-COVID reasons. We demonstrate a higher frequency of autoantibodies in the COVID-19 ITU group compared with non-COVID-19 ITU disease control patients and that autoantibodies were also found in the serum 3-5 months post-COVID-19 infection. Non-COVID patients displayed a diverse pattern of autoantibodies; in contrast, the COVID-19 groups had a more restricted panel of autoantibodies including skin, skeletal muscle and cardiac antibodies. Our results demonstrate that respiratory viral infection with SARS-CoV-2 is associated with the detection of a limited profile of tissue-specific autoantibodies, detectable using routine clinical immunology assays. Further studies are required to determine whether these autoantibodies are specific to SARS-CoV-2 or a phenomenon arising from severe viral infections and to determine the clinical significance of these autoantibodies.
  • |*Antibody Specificity[MESH]
  • |*Autoantibodies/blood/immunology[MESH]
  • |*COVID-19/blood/immunology[MESH]
  • |*SARS-CoV-2/immunology/metabolism[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Organ Specificity[MESH]


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