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10.1016/j.cmet.2021.05.015

http://scihub22266oqcxt.onion/10.1016/j.cmet.2021.05.015
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34081913!8133495!34081913
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suck abstract from ncbi


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pmid34081913      Cell+Metab 2021 ; 33 (8): 1577-1591.e7
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  • SARS-CoV-2 infection induces beta cell transdifferentiation #MMPMID34081913
  • Tang X; Uhl S; Zhang T; Xue D; Li B; Vandana JJ; Acklin JA; Bonnycastle LL; Narisu N; Erdos MR; Bram Y; Chandar V; Chong ACN; Lacko LA; Min Z; Lim JK; Borczuk AC; Xiang J; Naji A; Collins FS; Evans T; Liu C; tenOever BR; Schwartz RE; Chen S
  • Cell Metab 2021[Aug]; 33 (8): 1577-1591.e7 PMID34081913show ga
  • Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19. Single-cell RNA sequencing and immunostaining from ex vivo infections confirmed that multiple types of pancreatic islet cells were susceptible to SARS-CoV-2, eliciting a cellular stress response and the induction of chemokines. Upon SARS-CoV-2 infection, beta cells showed a lower expression of insulin and a higher expression of alpha and acinar cell markers, including glucagon and trypsin1, respectively, suggesting cellular transdifferentiation. Trajectory analysis indicated that SARS-CoV-2 induced eIF2-pathway-mediated beta cell transdifferentiation, a phenotype that could be reversed with trans-integrated stress response inhibitor (trans-ISRIB). Altogether, this study demonstrates an example of SARS-CoV-2 infection causing cell fate change, which provides further insight into the pathomechanisms of COVID-19.
  • |*Cell Transdifferentiation/drug effects[MESH]
  • |Acetamides/pharmacology[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Animals[MESH]
  • |COVID-19/mortality/*virology[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Cyclohexylamines/pharmacology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Eukaryotic Initiation Factor-2/metabolism[MESH]
  • |Female[MESH]
  • |Glucagon[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Insulin-Secreting Cells/drug effects/metabolism/pathology/*virology[MESH]
  • |Insulin/metabolism[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Phenotype[MESH]
  • |SARS-CoV-2/*pathogenicity[MESH]
  • |Signal Transduction[MESH]
  • |Tissue Culture Techniques[MESH]
  • |Trypsin/metabolism[MESH]
  • |Vero Cells[MESH]


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