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10.1016/j.cmet.2021.05.015 http://scihub22266oqcxt.onion/10.1016/j.cmet.2021.05.015 34081913!8133495!34081913     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Metab 2021 ; 33 (8): 1577-1591.e7 Nephropedia Template TP {{tp|p=34081913|t=2021. SARS-CoV-2 infection induces beta cell transdifferentiation |pdf=|usr=}}{{34081913}} gab.com Text SARS-CoV-2 infection induces beta cell transdifferentiation JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=34081913 #FOAvip Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19. Single-cell RNA sequencing and immunostaining from ex vivo infections confirmed that multiple types of pancreatic islet cells were susceptible to SARS-CoV-2, eliciting a cellular stress response and the induction of chemokines. Upon SARS-CoV-2 infection, beta cells showed a lower expression of insulin and a higher expression of alpha and acinar cell markers, including glucagon and trypsin1, respectively, suggesting cellular transdifferentiation. Trajectory analysis indicated that SARS-CoV-2 induced eIF2-pathway-mediated beta cell transdifferentiation, a phenotype that could be reversed with trans-integrated stress response inhibitor (trans-ISRIB). Altogether, this study demonstrates an example of SARS-CoV-2 infection causing cell fate change, which provides further insight into the pathomechanisms of COVID-19. Twit Text FOAVip SARS-CoV-2 infection induces beta cell transdifferentiation ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=34081913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34081913 #FOAvip English Wikipedia <ref>{{Cite pmid|34081913}}</ref> SARS-CoV-2 infection induces beta cell transdifferentiation #MMPMID34081913 Tang X; Uhl S; Zhang T; Xue D; Li B; Vandana JJ; Acklin JA; Bonnycastle LL; Narisu N; Erdos MR; Bram Y; Chandar V; Chong ACN; Lacko LA; Min Z; Lim JK; Borczuk AC; Xiang J; Naji A; Collins FS; Evans T; Liu C; tenOever BR; Schwartz RE; Chen S Cell Metab 2021[Aug]; 33 (8): 1577-1591.e7 PMID34081913show ga Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19. Single-cell RNA sequencing and immunostaining from ex vivo infections confirmed that multiple types of pancreatic islet cells were susceptible to SARS-CoV-2, eliciting a cellular stress response and the induction of chemokines. Upon SARS-CoV-2 infection, beta cells showed a lower expression of insulin and a higher expression of alpha and acinar cell markers, including glucagon and trypsin1, respectively, suggesting cellular transdifferentiation. Trajectory analysis indicated that SARS-CoV-2 induced eIF2-pathway-mediated beta cell transdifferentiation, a phenotype that could be reversed with trans-integrated stress response inhibitor (trans-ISRIB). Altogether, this study demonstrates an example of SARS-CoV-2 infection causing cell fate change, which provides further insight into the pathomechanisms of COVID-19. |*Cell Transdifferentiation/drug effects[MESH] |Acetamides/pharmacology[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Animals[MESH] |COVID-19/mortality/*virology[MESH] |Chlorocebus aethiops[MESH] |Cyclohexylamines/pharmacology[MESH] |Cytokines/metabolism[MESH] |Eukaryotic Initiation Factor-2/metabolism[MESH] |Female[MESH] |Glucagon[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Insulin-Secreting Cells/drug effects/metabolism/pathology/*virology[MESH] |Insulin/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Phenotype[MESH] |SARS-CoV-2/*pathogenicity[MESH] |Signal Transduction[MESH] |Tissue Culture Techniques[MESH] |Trypsin/metabolism[MESH] |Vero Cells[MESH]SARS-CoV-2 infection induces beta cell transdifferentiation (epmc).pdf DeepDyve Pubget Overpricing