Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


suck pdf from google scholar
unlimited free pdf from europmc34080738    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi

Nephropedia Template TP Text

Twit Text FOAVip

Twit Text #

English Wikipedia

  • Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns #MMPMID34080738
  • Christensen EE; Jorgensen MJ; Nore KG; Dahl TB; Yang K; Ranheim T; Huse C; Lind A; Nur S; Stiksrud B; Jenum S; Tonby K; Holter JC; Holten AR; Halvorsen B; Dyrhol-Riise AM
  • J Intern Med 2021[Sep]; 290 (3): 677-692 PMID34080738show ga
  • BACKGROUND: Prognostic markers for disease severity and identification of therapeutic targets in COVID-19 are urgently needed. We have studied innate and adaptive immunity on protein and transcriptomic level in COVID-19 patients with different disease severity at admission and longitudinally during hospitalization. METHODS: Peripheral blood mononuclear cells (PBMCs) were collected at three time points from 31 patients included in the Norwegian SARS-CoV-2 cohort study and analysed by flow cytometry and RNA sequencing. Patients were grouped as either mild/moderate (n = 14), severe (n = 11) or critical (n = 6) disease in accordance with WHO guidelines and compared with patients with SARS-CoV-2-negative bacterial sepsis (n = 5) and healthy controls (n = 10). RESULTS: COVID-19 severity was characterized by decreased interleukin 7 receptor alpha chain (CD127) expression in naive CD4 and CD8 T cells. Activation (CD25 and HLA-DR) and exhaustion (PD-1) markers on T cells were increased compared with controls, but comparable between COVID-19 severity groups. Non-classical monocytes and monocytic HLA-DR expression decreased whereas monocytic PD-L1 and CD142 expression increased with COVID-19 severity. RNA sequencing exhibited increased plasma B-cell activity in critical COVID-19 and yet predominantly reduced transcripts related to immune response pathways compared with milder disease. CONCLUSION: Critical COVID-19 seems to be characterized by an immune profile of activated and exhausted T cells and monocytes. This immune phenotype may influence the capacity to mount an efficient T-cell immune response. Plasma B-cell activity and calprotectin were higher in critical COVID-19 while most transcripts related to immune functions were reduced, in particular affecting B cells. The potential of these cells as therapeutic targets in COVID-19 should be further explored.
  • |*Transcriptome[MESH]
  • |Adaptive Immunity[MESH]
  • |Adult[MESH]
  • |B-Lymphocytes/immunology[MESH]
  • |CD4-Positive T-Lymphocytes/immunology[MESH]
  • |CD8-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19/*genetics/*immunology[MESH]
  • |Female[MESH]
  • |HLA-DR Antigens/immunology[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |Interleukin-2 Receptor alpha Subunit/immunology[MESH]
  • |Interleukin-7/immunology[MESH]
  • |Leukocyte L1 Antigen Complex/blood[MESH]
  • |Leukocytes, Mononuclear/*immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Monocytes/immunology[MESH]
  • |Phenotype[MESH]
  • |Programmed Cell Death 1 Receptor/immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]
  • |T-Lymphocytes, Regulatory/immunology[MESH]
  • |Thromboplastin/immunology/metabolism[MESH]

  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    677 3.290 2021